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DNA Nanotechnology-Based Supramolecular Assemblies for Targeted Biomedical Applications.

Ankur Singh1, Dhiraj Bhatia1,2

  • 1Biological Engineering, Indian Institute of Technology Gandhinagar, Palaj, Gandhinagar, Gujarat 382355, India E-mail: Dhiraj Bhatia.

Chemical Record (New York, N.Y.)
|May 9, 2022
PubMed
Summary

DNA biopolymers form advanced supramolecular assemblies like hydrogels and dendrimers. These biocompatible structures offer significant potential in diverse biomedical applications, driving innovation in healthcare.

Keywords:
AptamersBiomedical ApplicationsDNA dendrimersDNA hydrogelsDNA supramolecular assemblies

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Area of Science:

  • Biotechnology
  • Materials Science
  • Molecular Biology

Background:

  • DNA is a natural biopolymer with advantageous properties including biodegradability, biocompatibility, and non-toxicity.
  • These inherent characteristics make DNA an attractive candidate for creating advanced biomaterials.
  • Exploiting DNA's properties enables the development of high-order supramolecular assemblies.

Purpose of the Study:

  • To review the synthesis, characterization, and applications of DNA-based supramolecular assemblies.
  • To highlight key developments and emerging trends in DNA hydrogels and dendrimers.
  • To provide a perspective on the challenges and future outlook for DNA supramolecular structures.

Main Methods:

  • Review of scientific literature on DNA supramolecular assemblies.
  • Analysis of synthesis principles and characterization techniques.
  • Compilation of examples and case studies of applications.

Main Results:

  • DNA hydrogels (DNA-HG) and DNA dendrimers (DNA-DS) are promising supramolecular assemblies.
  • These structures exhibit significant potential in biomedical fields like cell biology, pharmacology, and healthcare.
  • Recent advancements show a rapid growth in the application of these DNA-based materials.

Conclusions:

  • DNA-based supramolecular assemblies offer versatile platforms for biomedical innovation.
  • Further research into synthesis and application development is crucial.
  • Addressing current challenges will unlock the full potential of DNA hydrogels and dendrimers in healthcare manufacturing.