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Cerebral Venous Thrombosis in COVID-19

Rajesh Benny1, Rakeshsingh K Singh1, Anil Venkitachalam2

  • 1Department of Neurology, Fortis Hospital, Mulund, Maharashtra, India.

Neurology India
|May 9, 2022
PubMed

Insights

COVID-19 can cause cerebral venous thrombosis (CVT), sometimes as an early or presenting symptom, even in mild cases. This study found no significant difference in outcomes between COVID-19-associated CVT and non-COVID CVT patients.

Area of Science:

  • Neurology
  • Infectious Diseases
  • Vascular Medicine

Background:

  • COVID-19 is known to induce a hypercoagulable state, increasing the risk of thrombotic events.
  • Thrombotic complications in COVID-19 are often observed in severe cases and later in the disease progression.
  • Cerebral venous thrombosis (CVT) has emerged as a potential complication associated with COVID-19.

Purpose of the Study:

  • To investigate the temporal relationship between COVID-19 onset and CVT.
  • To compare the clinical characteristics, risk factors, and outcomes of CVT patients with and without COVID-19.

Main Methods:

  • A multicentric, retrospective study was conducted from April 4 to October 15, 2020.
  • Adult patients with CVT, both SARS-CoV-2 positive (COVID-19 group) and negative (non-COVID group), were included.
  • Clinical profiles, CVT risk factors, COVID coagulopathy markers, imaging, and outcome determinants were analyzed.

Main Results:

  • The study included 18 COVID-19 patients and 43 non-COVID-19 CVT patients.
  • CVT presented as the initial manifestation in 14 COVID-19 patients, with 13 having non-severe disease.
  • Mortality and disability outcomes did not significantly differ between the COVID-19 and non-COVID-19 CVT groups.

Conclusions:

  • A potential association between COVID-19 and CVT is suggested.
  • CVT can be an early or presenting sign of COVID-19, even in mild infections.
  • Poor outcomes in CVT patients were linked to lower Glasgow Coma Scale scores, abnormal chest CT, severe COVID-19, and need for ventilation.
Abstract

Keywords:
COVID-19CVTCerebral venous thrombosisSARS-CoV-2

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