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Genetic Polymorphisms in DRD4 and Risk for Parkinson's Disease Among Eastern Indians
Sadhukhan Dipanwita1, Biswas Arindam2, Biswas Atanu3
1S. N. Pradhan Centre for Neurosciences, University of Calcutta, Kolkata, West Bengal, India.
Background:
Genetic factors, including causal gene and modifier genes, contribute significantly in PD pathogenesis in an ethnicity-dependent manner. Dopamine Receptor 4 (DRD4), involved in dopamine metabolism is one such modifier locus for PD.
Objective:
To identify the potential association of DRD4 polymorphic variants with PD among Eastern Indians.
Methods And Materials:
PD-related DRD4 variants were genotyped among 291 PD patients and 265 ethnically matched controls from Eastern India.
Results And Conclusion:
Among the three DRD4 variants, only the 120 bp duplicated allele [P = 0.036; Odds ratio: 1.323; 95% CI: 1.014-1.725] and its homozygous genotype [P = 0.034; Odds ratio: 1.452; 95% CI: 1.025-2.057] were found as risk factors for overall PD and sporadic PD among Eastern Indians. However, no other disease-associated variant or haplotype was identified. Therefore, in conclusion, our study demonstrates that DRD4 plays a small role in PD pathogenesis among Eastern Indians.
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