Related Experiment Video

Updated: Sep 24, 2025

Handwriting Analysis Indicates Spontaneous Dyskinesias in Neuroleptic Naïve Adolescents at High Risk for Psychosis
05:52

Handwriting Analysis Indicates Spontaneous Dyskinesias in Neuroleptic Naïve Adolescents at High Risk for Psychosis

Published on: November 21, 2013

15.0K

Schizencephaly and the Neurodevelopmental Model of Psychosis

Rahul Patwal1, Naveen Manohar Pai1, Sundarnag Ganjekar1

  • 1Departmen of Psychiatry, National Institute of Mental Health and Neuro Sciences, Hosur Road, Bangalore, Karnataka, India.

Neurology India
|May 9, 2022
PubMed
Abstract

Insights

This case report highlights a rare association between schizencephaly, a congenital brain disorder, and psychiatric symptoms like paranoia and emotional lability in a 50-year-old male. Findings suggest a link between neurodevelopmental abnormalities and complex psychiatric presentations.

Area of Science:

  • Neurology
  • Psychiatry
  • Neurodevelopmental Disorders

Background:

  • Schizencephaly is a rare congenital disorder affecting cerebral cortical development, often presenting with motor deficits, seizures, and cognitive impairment.
  • Magnetic Resonance Imaging (MRI) is the primary diagnostic tool for schizencephaly.
  • While neurological and cognitive issues are common, psychiatric manifestations are infrequently reported.

Observation:

  • A 50-year-old gentleman presented with a constellation of psychiatric symptoms including paranoia, irritability, impulsive spending, emotional lability, and circumstantial speech.
  • The patient's clinical presentation was investigated through a review of existing literature and case summarization.

Findings:

  • MRI results indicated findings consistent with closed-lip schizencephaly.
  • The patient's psychiatric symptoms are presented in the context of this neurodevelopmental disorder.

Implications:

  • This case contributes to understanding the neurodevelopmental model of psychiatric disorders.
  • It underscores the importance of considering functional neuroanatomy in the manifestation of psychiatric symptom dimensions.
  • Further research may elucidate the relationship between specific cortical malformations and psychiatric conditions.
Keywords:
Neuroanatomical modelneurodevelopmental modelpsychosisschizencephaly

More Related Videos

A Model of Epileptogenesis in Rhinal Cortex-Hippocampus Organotypic Slice Cultures10:05

A Model of Epileptogenesis in Rhinal Cortex-Hippocampus Organotypic Slice Cultures

Published on: March 18, 2021

7.1K
Rapid Detection of Neurodevelopmental Phenotypes in Human Neural Precursor Cells NPCs10:47

Rapid Detection of Neurodevelopmental Phenotypes in Human Neural Precursor Cells NPCs

Published on: March 2, 2018

10.1K

Related Concept Videos

Psychosis: Pathophysiology of Schizophrenia and Other Psychotic Disorders01:27

Psychosis: Pathophysiology of Schizophrenia and Other Psychotic Disorders

Schizophrenia is a neurodevelopmental disorder whose origins are rooted in complex genetic components. Despite our burgeoning understanding, the pathophysiology of this disorder remains incompletely deciphered.
Researchers have identified genetic factors that increase susceptibility to schizophrenia, underscoring the intricate interplay between genetics and environment in disease development. At the core of schizophrenia's pathophysiology is excessive dopaminergic neurotransmission within...
1.0K
Biological Causes of Schizophrenia01:29

Biological Causes of Schizophrenia

Schizophrenia, a severe psychiatric disorder, arises from a complex interplay of biological factors, including genetic predisposition, structural brain abnormalities, neurotransmitter dysregulation, and developmental irregularities. These factors collectively contribute to the onset and progression of the disorder, which typically manifests in late adolescence or early adulthood.
Genetic Factors in Schizophrenia
The genetic basis of schizophrenia is strongly supported by family and twin...
168
Psychological and Sociocultural Causes of Schizophrenia01:29

Psychological and Sociocultural Causes of Schizophrenia

Schizophrenia, a complex psychiatric disorder, has been historically misunderstood. Early psychological theories attributed its origins to childhood trauma and unresponsive parenting. However, contemporary research largely rejects these notions, favoring the vulnerability-stress hypothesis. This model proposes that individuals with a genetic predisposition to schizophrenia may develop the disorder following exposure to significant environmental stressors. Notably, studies on high-risk...
211
Schizophrenia01:17

Schizophrenia

Schizophrenia, a term introduced by Swiss psychiatrist Eugen Bleuler in 1911, describes a severe psychological disorder marked by profound disruptions in attention, thought processes, language, emotion, and interpersonal relationships. The core feature of schizophrenia is psychosis — a state characterized by a fundamental detachment from reality. This disconnection manifests through distorted logic, impaired perception, and atypical behavior, severely affecting the lives of those...
254
Psychosis and Antipsychotic Drugs: Overview01:28

Psychosis and Antipsychotic Drugs: Overview

The term "psychosis" refers to a spectrum of mental disorders characterized by abnormal thoughts, perceptions, and behaviors. It can manifest as mood disorders, dementia, delirium with psychotic features, substance-induced psychosis with psychotic features, brief psychotic disorder, delusional disorder, schizoaffective disorder, and schizophrenia. Among all these disorders, schizophrenia is the most common psychotic disorder, affecting 1% of the worldwide population. Psychotic...
487
Positive Symptoms of Schizophrenia: Hallucinations and Delusions01:30

Positive Symptoms of Schizophrenia: Hallucinations and Delusions

Schizophrenia is a complex mental health disorder that can manifest with various positive symptoms, including thought, movement, and behavior disorders. These symptoms significantly disrupt cognitive and motor functions, leading to profound effects on an individual's ability to engage with the world.
Thought Disorders
Disorganized and unusual thought processes mark thought disorders in schizophrenia. One key feature is disorganized speech, where an individual's conversation includes...
226