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Published on: June 4, 2021
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Microcavitation dynamics in viscoelastic tissue during histotripsy process
Ahmed K Abu-Nab1,2, Khaled G Mohamed3, Ali F Abu-Bakr1,4
1Department of Mathematics and Computer Science, Faculty of Science, Menoufia University, Shebin El-Koom 32511, Egypt.
Summary
Histotripsy uses microcavitation for non-invasive tissue ablation. This study analyzes bubble dynamics in viscoelastic media, finding that material properties like Young
Area of Science:
- Biomedical Engineering
- Acoustic Physics
- Materials Science
Background:
- Histotripsy is a non-invasive ultrasonic ablation technique.
- It relies on microcavitation to mechanically break down tissue.
- Understanding bubble dynamics is crucial for optimizing histotripsy.
Purpose of the Study:
- To analyze cavitation bubble dynamics in viscoelastic media during histotripsy.
- To compare different models for compressibility and viscoelasticity effects.
- To investigate the influence of material properties on bubble behavior.
Main Methods:
- Mathematical modeling using the Keller-Miksis equation.
- Two models for viscoelastic tissue: neo-Hookean and quadratic law Kelvin-Voigt.
- Analytical solution via the modified Plesset-Zwick method.
Main Results:
- Young's modulus, viscosity, and stiffening parameters reduce microbubble growth.
- Lower gel concentration increases cavitation bubble growth.
- Viscoelastic properties significantly affect bubble dynamics in histotripsy.
Conclusions:
- Material properties play a key role in controlling histotripsy effectiveness.
- The models provide insights into bubble dynamics for therapeutic ultrasound applications.
- Further research can refine histotripsy parameters for targeted tissue ablation.
