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Single-interface bioelectronic medicines-concept, clinical applications and preclinical data.

Cristian Sevcencu1,2

  • 1National Institute for Research and Development of Isotopic and Molecular Technologies (INCDTIM), 67-103 Donat Str, Cluj-Napoca, 400293, Romania.

Journal of Neural Engineering
|May 9, 2022
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Summary

Next-generation bioelectronic medicines offer closed-loop control for treating diseases unresponsive to traditional therapies. These single-interface devices aim to improve neurostimulation by monitoring and modulating neural signals for enhanced therapeutic outcomes.

Keywords:
bioelectronic medicinesclosed-loop controlneuromodulationvagus nerve

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Area of Science:

  • Biomedical Engineering
  • Neuroscience
  • Medical Devices

Background:

  • Many patients are intolerant or unresponsive to current drug therapies and surgical interventions.
  • Implantable neurostimulation is a third-line option but lacks closed-loop control and selective stimulation.
  • Existing neurostimulation therapies are suboptimal due to these limitations.

Purpose of the Study:

  • To review a new class of bioelectronic medicines with closed-loop control and selective capabilities.
  • To explore single-interface devices designed for monitoring and treating impaired functions via neural signal modulation.
  • To provide a broad perspective on the concept, clinical applications, and preclinical studies of these advanced devices.

Main Methods:

  • Narrative review of existing literature and research.
  • Analysis of the concept behind single-interface bioelectronic devices.
  • Examination of clinical applications and preclinical studies for future development.

Main Results:

  • Next-generation bioelectronic medicines with closed-loop control are emerging.
  • Single-interface devices integrate monitoring and treatment functions.
  • These devices offer potential for more precise and effective neural modulation.

Conclusions:

  • Bioelectronic medicines represent a significant advancement over current neurostimulation.
  • Single-interface devices hold promise for treating conditions refractory to conventional treatments.
  • Further preclinical and clinical studies are essential to realize the full potential of these therapies.