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Personalised immunotherapy in sepsis: a scoping review protocol.

Marleen A Slim1,2, Niels van Mourik3,2, Joanna C Dionne4,5,6,7

  • 1Intensive Care, Amsterdam UMC Location AMC, Amsterdam, The Netherlands m.a.slim@amsterdamumc.nl.

BMJ Open
|May 9, 2022
PubMed
Summary

This scoping review examines current literature on immunotherapies for sepsis, a severe infection causing organ dysfunction. It aims to summarize existing research on immunostimulatory and immunosuppressive treatments for sepsis patients.

Keywords:
Adult intensive & critical careClinical trialsINFECTIOUS DISEASESImmunology

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Area of Science:

  • Critical Care Medicine
  • Immunology
  • Infectious Diseases

Background:

  • Sepsis is a life-threatening organ dysfunction syndrome due to severe infections, posing a significant global health challenge with high mortality.
  • Current sepsis treatment is largely supportive, with limited targeted interventions despite advances in understanding its pathophysiology.
  • Research is increasingly focusing on immunomodulatory agents to address excessive inflammation and immunosuppression in sepsis.

Purpose of the Study:

  • To comprehensively review and summarize the available literature on immunostimulatory and immunosuppressive therapies for sepsis in adult patients.
  • To identify the types of immunotherapies currently being studied and those already investigated for sepsis treatment.
  • To provide an overview of the evidence base for immunomodulatory approaches in sepsis management.

Main Methods:

  • A scoping review methodology, following the Arksey and O'Malley framework, will be employed.
  • Literature searches will be conducted in PubMed, Embase, Cochrane CENTRAL, and ClinicalTrials.gov.
  • Data extraction and screening will be performed independently by two reviewers to ensure accuracy and reliability.

Main Results:

  • The review will summarize evidence on various immunotherapies investigated for sepsis.
  • Findings will include details on the types of immunomodulatory agents used and their application stages.
  • The results will highlight the current landscape of immunotherapy research in sepsis.

Conclusions:

  • This review will provide valuable insights into the current state of immunotherapy for sepsis.
  • The findings will be beneficial for clinicians and researchers aiming to improve sepsis care through targeted immunomodulation.
  • Understanding the existing evidence is crucial for guiding future research and clinical application of immunotherapies in sepsis.