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Published on: June 15, 2019
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Personalised immunotherapy in sepsis: a scoping review protocol.
Marleen A Slim1,2, Niels van Mourik3,2, Joanna C Dionne4,5,6,7
1Intensive Care, Amsterdam UMC Location AMC, Amsterdam, The Netherlands m.a.slim@amsterdamumc.nl.
BMJ Open
|May 9, 2022
Summary
This scoping review examines current literature on immunotherapies for sepsis, a severe infection causing organ dysfunction. It aims to summarize existing research on immunostimulatory and immunosuppressive treatments for sepsis patients.
Area of Science:
- Critical Care Medicine
- Immunology
- Infectious Diseases
Background:
- Sepsis is a life-threatening organ dysfunction syndrome due to severe infections, posing a significant global health challenge with high mortality.
- Current sepsis treatment is largely supportive, with limited targeted interventions despite advances in understanding its pathophysiology.
- Research is increasingly focusing on immunomodulatory agents to address excessive inflammation and immunosuppression in sepsis.
Purpose of the Study:
- To comprehensively review and summarize the available literature on immunostimulatory and immunosuppressive therapies for sepsis in adult patients.
- To identify the types of immunotherapies currently being studied and those already investigated for sepsis treatment.
- To provide an overview of the evidence base for immunomodulatory approaches in sepsis management.
Main Methods:
- A scoping review methodology, following the Arksey and O'Malley framework, will be employed.
- Literature searches will be conducted in PubMed, Embase, Cochrane CENTRAL, and ClinicalTrials.gov.
- Data extraction and screening will be performed independently by two reviewers to ensure accuracy and reliability.
Main Results:
- The review will summarize evidence on various immunotherapies investigated for sepsis.
- Findings will include details on the types of immunomodulatory agents used and their application stages.
- The results will highlight the current landscape of immunotherapy research in sepsis.
Conclusions:
- This review will provide valuable insights into the current state of immunotherapy for sepsis.
- The findings will be beneficial for clinicians and researchers aiming to improve sepsis care through targeted immunomodulation.
- Understanding the existing evidence is crucial for guiding future research and clinical application of immunotherapies in sepsis.
