Related Experiment Video
Updated: Sep 24, 2025
08:09
Isolation, Culture, and Imaging of Human Fetal Pancreatic Cell Clusters
Published on: May 18, 2014
14.4K
In vitro fertilization and hypertriglyceridemic pancreatitis: Case report
1Division of Endocrinology, UT Southwestern Medical Center, 5323 Harry Hines Blvd., Dallas, TX 75390-8857, United States.
Journal of Clinical Lipidology
|May 9, 2022
Summary
High-dose ethinyl estradiol during in vitro fertilization (IVF) may trigger severe hypertriglyceridemia and pancreatitis in susceptible women. This case highlights the importance of monitoring lipid levels during IVF treatments.
Area of Science:
- Reproductive Endocrinology
- Gastroenterology
- Critical Care Medicine
Background:
- Hypertriglyceridemic pancreatitis is a rare but serious complication.
- In vitro fertilization (IVF) involves hormonal treatments, including estrogen administration.
- Few cases link hypertriglyceridemic pancreatitis to IVF cycles.
Observation:
- A 41-year-old woman with a history of pancreatitis developed hypertriglyceridemic pancreatitis during an IVF cycle.
- She was receiving high-dose ethinyl estradiol for endometrial preparation.
- Symptoms included severe nausea, vomiting, and abdominal pain, requiring intensive care and plasmapheresis.
Findings:
- Ethinyl estradiol administration was associated with a significant increase in triglyceride levels.
- Discontinuation of ethinyl estradiol, supportive care, and lipid-lowering treatments led to symptom resolution.
- This case adds to the limited reports of hypertriglyceridemic pancreatitis during IVF, specifically during cryopreserved embryo transfer.
Implications:
- Exogenous estrogen, like ethinyl estradiol, may predispose certain individuals to severe hypertriglyceridemia and pancreatitis during IVF.
- Vigilant monitoring of lipid profiles in women undergoing IVF, particularly those with risk factors, is crucial.
- Further research is needed to elucidate the mechanisms of estrogen's effect on lipid metabolism in the context of assisted reproductive technologies.
Related Concept Videos
01:30Acute Pancreatitis II: Clinical Manifestations and Management
187
Acute pancreatitis presents a complex medical emergency characterized by rapid onset inflammation of the pancreas, demanding timely diagnosis and management to prevent complications. The condition primarily manifests through severe upper abdominal pain that often radiates to the back. This pain intensifies following the consumption of fatty foods. Accompanying symptoms such as nausea, vomiting, abdominal distention, fever, dyspnea, cyanosis, and jaundice can vary in intensity but significantly...
187
01:24Chronic Pancreatitis I: Introduction
178
The pancreas, an elongated and flat gland situated behind the stomach, serves a vital function in digesting food and managing blood sugar levels.
Pancreatitis is the inflammation of the pancreas, which occurs when the immune system becomes active and causes swelling, pain, and disruptions in organ function. Pancreatitis can manifest as either an acute or chronic condition.
Acute pancreatitis arises suddenly and lasts for a brief duration, while chronic pancreatitis is a long-term affliction...
Pancreatitis is the inflammation of the pancreas, which occurs when the immune system becomes active and causes swelling, pain, and disruptions in organ function. Pancreatitis can manifest as either an acute or chronic condition.
Acute pancreatitis arises suddenly and lasts for a brief duration, while chronic pancreatitis is a long-term affliction...
178
01:29Chronic Pancreatitis II: Collaborative Care
133
The management of chronic pancreatitis is multifaceted, involving a comprehensive approach that includes thorough assessment, diagnostic testing, and a variety of management strategies.
Assessment:
Assessment:
133
01:27Acute Pancreatitis I: Introduction
510
Pancreatitis is inflammation of the pancreas, an organ located behind the stomach. It can be either acute or chronic.
Acute pancreatitis is characterized by rapid inflammation of the pancreas, often caused by factors like gallstone blockage or excessive alcohol consumption. Chronic pancreatitis, on the other hand, is a slow, progressive inflammation that may result from long-term alcohol abuse, obstructions in the pancreatic duct, or genetic factors.
The causes of acute pancreatitis include:
Acute pancreatitis is characterized by rapid inflammation of the pancreas, often caused by factors like gallstone blockage or excessive alcohol consumption. Chronic pancreatitis, on the other hand, is a slow, progressive inflammation that may result from long-term alcohol abuse, obstructions in the pancreatic duct, or genetic factors.
The causes of acute pancreatitis include:
510