Cross reactivity of anti-epithelial membrane antigen monoclonal for reactive and neoplastic glial cells

An anti-epithelial membrane antigen monoclonal (Clone E29) was used as part of a panel of antisera in the investigation of primary CNS and metastatic tumours. In contrast to others, definite and often strongly positive cross-reactivity has been demonstrated on glial cells. The material consisted of fourteen astrocytomas, two ependymomas, six cerebral metastases and two cases of gliosis.