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Non-coding RNAs associated with autophagy and their regulatory role in cancer therapeutics

Surbhi Kumari Barnwal1, Hrushikesh Bendale1, Satarupa Banerjee2

  • 1School of Biosciences and Technology, Vellore Institute of Technology, Tamil Nadu, Vellore, 632014, India.

Molecular Biology Reports
|May 9, 2022
PubMed

Insights

Non-coding RNAs (ncRNAs) influence cancer progression by modulating autophagy, a cellular self-degradation process. This review explores how ncRNAs impact autophagy and cancer signaling pathways in various cancers.

Area of Science:

  • Oncology
  • Molecular Biology
  • Genetics

Background:

  • Cancer is a leading global cause of death with poor prognosis for many types.
  • Autophagy, a cellular degradation process, plays a dual role in cancer progression, potentially promoting or inhibiting tumor growth.
  • Non-coding RNAs (ncRNAs) are crucial regulators of gene expression and have emerged as key players in cellular processes.

Purpose of the Study:

  • To review the involvement of ncRNAs in autophagy.
  • To explore the modulation of cancer signal transduction pathways by ncRNAs and autophagy.
  • To highlight the role of ncRNAs in various cancers including lung, breast, prostate, pancreatic, thyroid, and kidney cancer.

Main Methods:

  • Literature review focusing on studies investigating ncRNAs, autophagy, and cancer.
  • Analysis of ncRNA interactions with autophagy-related genes and pathways.
  • Examination of ncRNA-mediated regulation of cancer signaling in different tumor types.

Main Results:

  • ncRNAs, including lncRNAs, miRNAs, and circRNAs, significantly impact autophagy.
  • ncRNAs can influence autophagy-dependent cell death and non-apoptotic cell death in cancer.
  • Dysregulation of ncRNAs is linked to altered autophagy and cancer progression.

Conclusions:

  • ncRNAs are critical regulators of autophagy in cancer.
  • Targeting ncRNAs offers potential therapeutic strategies for modulating autophagy in cancer treatment.
  • Further research into ncRNA-autophagy interactions is essential for understanding and combating cancer.
Keywords:
ApoptosisAutophagyCancerTherapeuticsncRNA

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