Self-Emulsifying Systems for Delivery of Bioactive Compounds from Natural Origin

Area of Science:

• Pharmacology
• Materials Science
• Natural Products Chemistry

Background:

• Natural products have a long history of therapeutic use.
• Poor water solubility limits the bioavailability of many natural compounds.
• Advanced delivery systems are needed to overcome these limitations.

Purpose of the Study:

• To provide a comprehensive review of self-emulsifying drug delivery systems (SEDDS) for natural bioactive compounds.
• To discuss excipients, natural compounds, applications, and innovations in SEDDS technology.
• To highlight the role of SEDDS in improving the delivery of hydrophobic natural substances.

Main Methods:

• Literature review of scientific publications on SEDDS and natural compounds.
• Analysis of excipients, bioactive compounds, and formulation strategies.
• Examination of various administration routes and their impact on delivery.

Main Results:

• SEDDS, composed of oils and surfactants, effectively form emulsions for hydrophobic compounds.
• Numerous self-emulsifying formulations incorporating natural bioactive compounds have been developed.
• SEDDS significantly enhance solubility, absorption, and bioavailability of natural drugs.

Conclusions:

• SEDDS represent a promising strategy for delivering poorly soluble natural compounds.
• The review covers key components, applications, and emerging technologies in SEDDS for natural products.
• Understanding SEDDS administration is crucial for optimizing the delivery of natural therapeutics.