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Attenuation of exercise conditioning by metformin-a consequence of HSF1 inhibition

Philip L Hooper1

  • 1Division of Endocrinology and Metabolism, Department of Medicine, University of Colorado Anschutz Medical Campus, Aurora, CO, USA. phoopermd@gmail.com.

Cell Stress & Chaperones
|May 9, 2022
PubMed
Abstract

No abstract available in PubMed .

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Biguanides, particularly metformin (Glucophage), are insulin sensitizers that enhance glucose uptake, thereby reducing insulin resistance. Unlike sulfonylureas, metformin doesn't prompt insulin secretion, which helps to curb hypoglycemia risk. Metformin is beneficial in treating conditions like polycystic ovary syndrome due to its insulin-resistance reduction capability. The drug's primary action involves curtailing hepatic gluconeogenesis, a significant contributor to high blood...
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