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Updated: Sep 24, 2025

Rating L-DOPA-Induced Dyskinesias in the Unilaterally 6-OHDA-Lesioned Rat Model of Parkinson's Disease
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D1/D5 Inverse Agonists Restore Striatal Cholinergic Interneuron Physiology in Dyskinetic Mice

Rodrigo Manuel Paz1, Agostina Mónica Stahl1, Lorena Rela1

  • 1Universidad de Buenos Aires, CONICET, Instituto de Fisiología y Biofísica (IFIBIO) Bernardo Houssay, Grupo de Neurociencia de Sistemas, Buenos Aires, Argentina.

Movement Disorders : Official Journal of the Movement Disorder Society
|May 10, 2022
PubMed
Summary

Aberrant striatal cholinergic interneuron (SCIN) activity contributes to Parkinson's disease (PD) motor symptoms. Targeting the D5-cAMP-ERK1/2 pathway in SCINs offers a promising therapeutic strategy for PD and dyskinesia.

Keywords:
l-dopa-induced dyskinesiaParkinson's diseasestriatal cholinergic interneurons

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