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D-dimer to Creatinine Ratio: A Novel Biomarker Associated with Gensini Score in ST-Segment Elevation Myocardial

Jiaojiao Yang1,2, Yingjie Zhao3, Yong Li4

  • 1Department of Gastroenterology, Songjiang Hospital Affiliated to Shanghai Jiao Tong University School of Medicine (Preparatory Stage), Shanghai, China.

Clinical and Applied Thrombosis/Hemostasis : Official Journal of the International Academy of Clinical and Applied Thrombosis/Hemostasis
|May 10, 2022
PubMed

Insights

The D-dimer to creatinine ratio (DCR) shows promise as a clinical biomarker for ST-segment elevation myocardial infarction (STEMI). Higher DCR levels correlate with more severe coronary artery disease in STEMI patients.

Area of Science:

  • Cardiology
  • Biomarker Discovery
  • Myocardial Infarction Research

Background:

  • ST-segment elevation myocardial infarction (STEMI) is a critical cardiovascular event.
  • Identifying reliable biomarkers for assessing STEMI severity is crucial for patient management.
  • The D-dimer to creatinine ratio (DCR) has not been previously explored as a biomarker in STEMI.

Purpose of the Study:

  • To investigate the potential of the D-dimer to creatinine ratio (DCR) as a novel clinical biomarker in STEMI patients.
  • To explore the association between DCR and the severity of coronary artery disease, as assessed by the Gensini score.

Main Methods:

  • Analysis included 347 STEMI patients with complete D-dimer and creatinine measurements.
  • Patients were stratified into lower and higher DCR groups based on the median value.
  • Coronary artery disease severity was quantified using the Gensini score and categorized into four groups.
  • Multivariate regression analyses were employed to identify independent predictors of Gensini score.

Main Results:

  • The higher DCR group exhibited a significantly higher Gensini score compared to the lower DCR group (P < .05).
  • DCR demonstrated a positive correlation with the Gensini score (r = 0.493, P < .001).
  • DCR was identified as an independent risk factor associated with the Gensini score, alongside Previous MI.

Conclusions:

  • The D-dimer to creatinine ratio (DCR) is a novel and potentially useful clinical biomarker in STEMI.
  • DCR is positively correlated with the coronary Gensini score, indicating its association with disease severity.
  • Elevated DCR levels are independently associated with increased coronary artery disease severity in STEMI patients.
Abstract

Keywords:
D-dimerD-dimer to creatinine ratioGensini scoreST-elevation myocardial infarctioncreatinine

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