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Updated: Sep 24, 2025
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An In vitro System to Gauge the Thrombolytic Efficacy of Histotripsy and a Lytic Drug
Published on: June 4, 2021
2.8K
High-spatial-resolution, instantaneous passive cavitation imaging with temporal resolution in histotripsy: a
Mok Kun Jeong1, Min Joo Choi2, Sung Jae Kwon3
1Department of Electronic Engineering, Daejin University, Pocheon, Korea.
Ultrasonography (Seoul, Korea)
|May 10, 2022
Summary
A new passive cavitation (PC) imaging method improves tissue disruption monitoring in histotripsy. This technique accurately tracks cavitation occurrence and location, enhancing shock wave therapy.
Area of Science:
- Medical Imaging
- Acoustic Cavitation Physics
Background:
- Histotripsy uses shock waves and cavitation to disrupt tissue.
- Current passive cavitation (PC) imaging lacks temporal and spatial resolution.
Purpose of the Study:
- Develop an improved PC imaging method for histotripsy.
- Enable real-time detection and tracking of cavitation events.
Main Methods:
- Constructed instantaneous PC images using delay and sum beamforming.
- Applied beamforming at discrete time instants for temporal analysis.
- Masked side lobes to enhance spatial resolution of cavitation signals.
Main Results:
- Simulations demonstrated higher resolution compared to integrated PC imaging.
- The method accurately determined cavitation position, timing, and signal strength.
- Successfully detected individual cavitation events at low incidence.
Conclusions:
- The novel PC imaging method enables precise monitoring of histotripsy treatments.
- It facilitates real-time tracking of cavitation, crucial for shock wave therapies.
- This advancement aids in optimizing treatment efficacy and safety.
