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Biofilms are complex communities of microorganisms encased in a self-produced extracellular polysaccharide matrix attached to surfaces. These microbial consortia can include single or multiple species, providing enhanced survival benefits by forming organized, multilayered structures.The formation of biofilms occurs through four key stages: attachment, colonization, development, and dispersal.During attachment, free-swimming planktonic cells adhere to a surface, often facilitated by...

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Effects of Mechanical Methods Used in Peri-implantitis Treatment on Implant Surface Decontamination and Roughness

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Light-Propelled Nanorobots for Facial Titanium Implants Biofilms Removal.

Martina Ussia¹, Mario Urso¹, Stepan Kment^2,3

¹Future Energy and Innovation Laboratory, Central European Institute of Technology, Brno University of Technology, Purkyňova 123, Brno, 612 00, Czech Republic.

Small (Weinheim an Der Bergstrasse, Germany)

|May 10, 2022

Summary

Researchers developed light-driven nanorobots to combat bacterial biofilms on titanium miniplates used in maxillofacial surgery. These nanorobots effectively reduced biofilm biomass, offering a promising new therapy for infected implants.

Keywords:

UV light bacteria black TiO 2 dental implants nanomotors silver visible light

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Area of Science:

Biomaterials Science
Nanotechnology
Oral and Maxillofacial Surgery

Background:

Titanium miniplates are crucial in maxillofacial surgery but susceptible to biofilm infections, leading to inflammation and implant failure.
Current treatments for infected implants often require removal, highlighting the need for novel therapeutic strategies.
Bacterial biofilms on medical implants pose a significant clinical challenge, necessitating advanced antimicrobial approaches.

Purpose of the Study:

To investigate the efficacy of light-driven nanorobots against multispecies bacterial biofilms on titanium miniplates.
To simulate oral microenvironment conditions and pathogenic challenges relevant to infected maxillofacial implants.
To evaluate the motion characteristics and biofilm eradication capabilities of novel nanorobots.

Main Methods:

Utilized self-propelled tubular black-TiO₂ /Ag nanorobots actuated by UV to visible light.
Analyzed nanorobot motion under different light wavelengths (UV, blue, green).
Quantified biofilm biomass reduction using LIVE/DEAD fluorescence and digital microscopy after nanorobot treatment.

Main Results:

Nanorobots demonstrated light-dependent motion, with rotational speed decreasing as light wavelength increased.
Significant reduction in bacterial biofilm biomass was observed following nanorobot treatment.
The study confirmed the potential of nanorobots in combating biofilms on titanium implants under simulated oral conditions.

Conclusions:

Light-driven nanorobots show promise as an effective therapeutic strategy for treating bacterial biofilm infections on titanium miniplates.
This approach offers a potential alternative to surgical removal of infected implants.
Further development could lead to advanced treatments for implant-associated infections in oral and maxillofacial surgery.