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Related Concept Videos

Peripheral Arterial Disease II: Clinical Manifestations and Diagnostic Evaluation01:21

Peripheral Arterial Disease II: Clinical Manifestations and Diagnostic Evaluation

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Clinical manifestationsPeripheral Arterial Disease (PAD) manifests through a range of symptoms, from the characteristic intermittent claudication to atypical presentations and severe complications in advanced stages. Intermittent claudication, a hallmark symptom of PAD, presents as exercise-induced muscle pain that typically resolves within minutes of rest. This pain is reproducible and stems from inadequate blood flow, leading to the accumulation of lactic acid produced during anaerobic...
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Venous Thrombosis II: Clinical Manifestations and Diagnostic Studies01:20

Venous Thrombosis II: Clinical Manifestations and Diagnostic Studies

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The key difference between Superficial Vein Thrombosis (SVT) and Deep Vein Thrombosis (DVT) lies in their location and severity.Clinical ManifestationsSVT typically presents with localized pain, tenderness, and redness along the course of a superficial vein, often accompanied by a palpable, cord-like structure under the skin. This condition is usually less dangerous than DVT but can be uncomfortable and may lead to complications such as cellulitis or, rarely, a clot extension into the deep...
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Varicose Veins II: Diagnostic Studies and Interprofessional Care01:26

Varicose Veins II: Diagnostic Studies and Interprofessional Care

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Varicose veins, or varicosities, develop when the valves in the veins, which control blood flow, weaken or damage. It causes blood to pool and the veins to enlarge. Understanding the clinical manifestations, diagnostic approaches, and management options for varicose veins is crucial for effective treatment and relief.Clinical manifestationsClinical manifestations of varicose veins include a heavy, achy feeling or pain after prolonged standing or sitting. This discomfort can often be relieved by...
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Endocarditis II: Clinical Features of Infective Endocarditis01:25

Endocarditis II: Clinical Features of Infective Endocarditis

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Endocarditis can present various clinical features depending on the causative organism and the patient's underlying health conditions. Initially, the clinical features of infective endocarditis develop gradually, presenting with nonspecific symptoms that can be easily mistaken for other illnesses.General SymptomsEarly symptoms of infective endocarditis are fever, chills, weakness, malaise, fatigue, and weight loss. These symptoms reflect the systemic nature of the infection and the body's...
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Imaging Studies VII: Vascular Imaging01:19

Imaging Studies VII: Vascular Imaging

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DefinitionRenal angiography, also known as renal arteriography, is an imaging technique used to obtain a comprehensive view of blood flow and the vascular structure of blood vessels in the kidneys and surrounding areas.PurposeRenal angiography detects blood vessel abnormalities in the kidneys, such as aneurysms, stenosis, thrombosis, vascular tumors, and renal artery stenosis. It evaluates kidney function and guides interventional treatments like angioplasty or stent placement.Pre-Procedure...
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Rheumatic Heart Disease II: Clinical Manifestations and Diagnostic Studies01:22

Rheumatic Heart Disease II: Clinical Manifestations and Diagnostic Studies

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The key clinical manifestations of Rheumatic heart disease (RHD) include several distinct cardiac symptoms.Carditis, a hallmark of acute rheumatic fever, involves inflammation of the heart's endocardium, myocardium, and pericardium. Chronic RHD often results from recurrent episodes of carditis. Its symptoms include the following:Murmurs are caused by valvular damage, especially to the mitral and aortic valves. Mitral stenosis or regurgitation is common, with characteristic heart murmurs...
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Expert perspectives on pathological findings in vasculitis.

Akihiro Ishizu1, Tamihiro Kawakami2, Hiroyuki Kanno3

  • 1Department of Medical Laboratory Science, Faculty of Health Sciences, Hokkaido University, Sapporo, Japan.

Modern Rheumatology
|May 10, 2022
PubMed
Summary

This guide details pathological findings for diagnosing vasculitis, a rare disease. It covers the 2012 International Chapel Hill Consensus Conference Nomenclature of Vasculitides (CHCC2012) classifications and related conditions for clinical reference.

Keywords:
CHCC2012granulomatous vasculitisleucocytoclastic vasculitisnecrotizing vasculitis

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Area of Science:

  • Pathology
  • Rheumatology
  • Medical Diagnostics

Background:

  • Pathological findings are crucial for diagnosing vasculitis.
  • Rarity of vasculitis makes comprehensive understanding challenging for non-specialists.
  • Existing resources offer limited information on vasculitis pathology.

Purpose of the Study:

  • To present representative pathological findings in vasculitis.
  • To classify vasculitides according to the 2012 Revised International Chapel Hill Consensus Conference Nomenclature of Vasculitides (CHCC2012).
  • To aid clinicians in identifying typical pathological features of vasculitis.

Main Methods:

  • Classification of 26 vasculitides into seven categories based on CHCC2012.
  • Inclusion of large-vessel, medium-vessel, and small-vessel vasculitis (including ANCA-associated and immune complex types).
  • Presentation of vasculitis-related diseases and non-inflammatory vasculopathy.

Main Results:

  • Detailed pathological descriptions for each CHCC2012 category.
  • Illustrations of characteristic histopathological features.
  • Distinction between inflammatory vasculitis and non-inflammatory vasculopathy.

Conclusions:

  • Provides a comprehensive reference for vasculitis pathology.
  • Enhances diagnostic accuracy for clinicians in daily practice.
  • Supports better understanding of the diverse spectrum of vasculitis.