Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Psychological and Sociocultural Causes of Schizophrenia01:29

Psychological and Sociocultural Causes of Schizophrenia

211
Schizophrenia, a complex psychiatric disorder, has been historically misunderstood. Early psychological theories attributed its origins to childhood trauma and unresponsive parenting. However, contemporary research largely rejects these notions, favoring the vulnerability-stress hypothesis. This model proposes that individuals with a genetic predisposition to schizophrenia may develop the disorder following exposure to significant environmental stressors. Notably, studies on high-risk...
211
Biological Causes of Schizophrenia01:29

Biological Causes of Schizophrenia

168
Schizophrenia, a severe psychiatric disorder, arises from a complex interplay of biological factors, including genetic predisposition, structural brain abnormalities, neurotransmitter dysregulation, and developmental irregularities. These factors collectively contribute to the onset and progression of the disorder, which typically manifests in late adolescence or early adulthood.
Genetic Factors in Schizophrenia
The genetic basis of schizophrenia is strongly supported by family and twin...
168
Psychosis: Pathophysiology of Schizophrenia and Other Psychotic Disorders01:27

Psychosis: Pathophysiology of Schizophrenia and Other Psychotic Disorders

1.0K
Schizophrenia is a neurodevelopmental disorder whose origins are rooted in complex genetic components. Despite our burgeoning understanding, the pathophysiology of this disorder remains incompletely deciphered.
Researchers have identified genetic factors that increase susceptibility to schizophrenia, underscoring the intricate interplay between genetics and environment in disease development. At the core of schizophrenia's pathophysiology is excessive dopaminergic neurotransmission within...
1.0K
Genome-wide Association Studies-GWAS01:11

Genome-wide Association Studies-GWAS

14.5K
Genome-wide association studies or GWAS are used to identify whether common SNPs are associated with certain diseases. Suppose specific SNPs are more frequently observed in individuals with a particular disease than those without the disease. In that case, those SNPs are said to be associated with the disease. Chi-square analysis is performed to check the probability of the allele likely to be associated with the disease.
GWAS does not require the identification of the target gene involved in...
14.5K
Human Genetics01:28

Human Genetics

750
Human genetics provides a profound framework for understanding the interplay between genetic predispositions and human psychology. At the heart of this discipline lies the study of how genes influence physical traits, behaviors, and susceptibility to diseases. Each person carries a unique genetic code that subtly or significantly shapes their psychological and behavioral landscape.
The complex relationship between genetics and psychology is observable through common biological components such...
750
Behavioral Genetics and Its Designs01:23

Behavioral Genetics and Its Designs

562
Behavior genetics explores how genetic inheritance influences human behavior. It focuses on how genes, passed from parents to offspring, contribute to the development of behavioral traits and tendencies. This branch of genetics seeks to understand the complex interplay between inherited genetic factors and environmental influences in shaping our behaviors.
The primary methodologies used in behavior genetics include family studies, twin studies, and adoption studies, each providing unique...
562

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Static stretching duration-dependent changes in flexibility, muscle oxygen saturation, and blood flow in the forearm flexors.

Scientific reports·2026
Same author

Quantitative evaluation of pyuria with a hemocytometer in children on clean intermittent catheterization.

Journal of infection and chemotherapy : official journal of the Japan Society of Chemotherapy·2026
Same author

Scientific Basis of Tolerable Daily Intake Derivation in Japan: Analysis of Study Types, Uncertainty Factors, and Critical Effect Levels in FSCJ Risk Assessment Reports.

Food safety (Tokyo, Japan)·2026
Same author

Prolonged cholestasis following severe neonatal echovirus 11 (genotype D5, new lineage 1) infection diagnosed by serum detection.

Journal of infection and chemotherapy : official journal of the Japan Society of Chemotherapy·2026
Same author

A Preliminary Open-Label Pilot Study of a Pillow-Based ELF-ELME (Extremely Low-Frequency, Extremely Low Magnetic Environment) Intervention for Major Depressive Disorder.

Neuropsychopharmacology reports·2026
Same author

Descriptive Epidemiology of Aerococcus urinae Isolated From Urine Cultures in a Pediatric Hospital: A Case Series.

Pediatrics international : official journal of the Japan Pediatric Society·2026

Related Experiment Video

Updated: Sep 24, 2025

A Strategy to Identify de Novo Mutations in Common Disorders such as Autism and Schizophrenia
05:51

A Strategy to Identify de Novo Mutations in Common Disorders such as Autism and Schizophrenia

Published on: June 15, 2011

26.0K

Shared genetic components between metabolic syndrome and schizophrenia: Genetic correlation using multipopulation

Rei Aoki1, Takeo Saito1, Kohei Ninomiya1

  • 1Department of Psychiatry, Fujita Health University School of Medicine, Toyoake, Japan.

Psychiatry and Clinical Neurosciences
|May 10, 2022
PubMed
Summary

This study found shared genetic links between schizophrenia and metabolic syndrome traits. Interestingly, genetic predisposition to schizophrenia was associated with lower metabolic syndrome risk, suggesting environmental factors drive these conditions in patients.

Keywords:
C-reactive proteinblood pressurebody mass indexcholesteroltriglycerides

More Related Videos

Derivation, Expansion, Cryopreservation and Characterization of Brain Microvascular Endothelial Cells from Human Induced Pluripotent Stem Cells
08:04

Derivation, Expansion, Cryopreservation and Characterization of Brain Microvascular Endothelial Cells from Human Induced Pluripotent Stem Cells

Published on: November 19, 2020

6.6K
Large-Scale Multi-Omics Genome-Wide Association Studies Mo-GWAS: Guidelines for Sample Preparation and Normalization
08:27

Large-Scale Multi-Omics Genome-Wide Association Studies Mo-GWAS: Guidelines for Sample Preparation and Normalization

Published on: July 27, 2021

3.8K

Related Experiment Videos

Last Updated: Sep 24, 2025

A Strategy to Identify de Novo Mutations in Common Disorders such as Autism and Schizophrenia
05:51

A Strategy to Identify de Novo Mutations in Common Disorders such as Autism and Schizophrenia

Published on: June 15, 2011

26.0K
Derivation, Expansion, Cryopreservation and Characterization of Brain Microvascular Endothelial Cells from Human Induced Pluripotent Stem Cells
08:04

Derivation, Expansion, Cryopreservation and Characterization of Brain Microvascular Endothelial Cells from Human Induced Pluripotent Stem Cells

Published on: November 19, 2020

6.6K
Large-Scale Multi-Omics Genome-Wide Association Studies Mo-GWAS: Guidelines for Sample Preparation and Normalization
08:27

Large-Scale Multi-Omics Genome-Wide Association Studies Mo-GWAS: Guidelines for Sample Preparation and Normalization

Published on: July 27, 2021

3.8K

Area of Science:

  • Genetics
  • Psychiatry
  • Metabolic Disorders

Background:

  • The genetic underpinnings connecting schizophrenia (SCZ) with nonpsychiatric disorders are not well understood.
  • Investigating shared genetic factors can elucidate disease mechanisms and identify potential therapeutic targets.

Purpose of the Study:

  • To examine the shared genetic components between schizophrenia and various nonpsychiatric traits using multi-population datasets.
  • To determine if genetic correlations between SCZ and metabolic syndrome traits exist and if they imply causality.

Main Methods:

  • Utilized genome-wide association study data from East Asian (EAS) and European (EUR) populations for SCZ.
  • Analyzed nonpsychiatric traits (complex disorders, laboratory values) from Biobank Japan (EAS) and UK Biobank (EUR).
  • Employed linkage disequilibrium score regression and meta-analysis for genetic correlation, followed by Mendelian randomization for causal inference.

Main Results:

  • Significant genetic correlations were found between SCZ and several metabolic syndrome (MetS) traits, including body mass index, high-density-lipoprotein cholesterol, blood sugar, triglycerides, systolic blood pressure, and C-reactive protein.
  • Meta-analysis across EAS and EUR samples confirmed these genetic correlations.
  • Mendelian randomization analysis did not detect a causal relationship between these metabolic traits and SCZ susceptibility.

Conclusions:

  • Shared genetic components exist between schizophrenia and metabolic syndrome traits, as well as C-reactive protein.
  • The observed genetic correlation between MetS traits and SCZ was inverse to clinical expectations, suggesting reduced MetS risk with genetic SCZ susceptibility.
  • Environmental factors, not genetic components, likely contribute to MetS in SCZ patients, influenced by treatments, lifestyle, and living conditions.