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Clinical perspectives on vagus nerve stimulation: present and future
Eibhlin Goggins1, Shuhei Mitani2, Shinji Tanaka2
1Division of Nephrology and Center for Immunity, Inflammation, and Regenerative Medicine, University of Virginia, Charlottesville, VA, U.S.A.
Clinical Science (London, England : 1979)
|May 10, 2022
Summary
Vagus nerve stimulation (VNS) shows potential for treating various diseases by modulating bodily functions. This review covers preclinical and clinical evidence, recent advancements, and the mechanisms underlying VNS efficacy.
Area of Science:
- Neuroscience
- Medical Technology
- Pharmacology
Background:
- The vagus nerve, a key component of the autonomic nervous system, influences numerous physiological processes.
- Vagus nerve stimulation (VNS) is an emerging neuromodulatory technique with broad therapeutic potential.
- Significant research interest exists across multiple disciplines regarding VNS's capabilities.
Purpose of the Study:
- To review current preclinical and clinical evidence for VNS efficacy in various diseases.
- To highlight recent advancements in VNS research and application.
- To examine studies providing insights into the mechanisms of VNS.
Main Methods:
- Systematic review of preclinical studies.
- Analysis of clinical trial data.
- Literature search for mechanistic studies.
Main Results:
- VNS demonstrates efficacy in preclinical models of diverse diseases.
- Clinical evidence supports VNS in specific conditions, with ongoing trials expanding its scope.
- Recent studies are elucidating the complex mechanisms through which VNS exerts its effects.
Conclusions:
- VNS is a promising therapeutic modality with a growing evidence base.
- Further research into VNS mechanisms will likely enhance its clinical application.
- VNS holds potential for modulating a wide range of physiological functions and treating diseases.
