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Disorders of phosphate homeostasis in children, part 2: hypophosphatemic and hyperphosphatemic disorders

Richard M Shore1,2

  • 1Department of Medical Imaging, Ann & Robert H. Lurie Children's Hospital of Chicago, 225 E. Chicago Ave., Chicago, IL, 60611, USA. rmashore@gmail.com.

Pediatric Radiology
|May 10, 2022
PubMed

Insights

This review covers pediatric phosphate disorders, including hypophosphatemia and hyperphosphatemia. It highlights fibroblast growth factor-23 (FGF23) signaling abnormalities impacting phosphate homeostasis.

Area of Science:

  • Pediatric Endocrinology
  • Skeletal Physiology
  • Biochemistry

Background:

  • Phosphate is crucial for physiological functions, bone mineralization, and skeletal cell regulation.
  • Fibroblast growth factor-23 (FGF23) is a key bone-derived hormone regulating phosphate homeostasis.
  • Disorders of phosphate balance can significantly impact skeletal health in children.

Purpose of the Study:

  • To review hypophosphatemic and hyperphosphatemic disorders in children.
  • To emphasize conditions related to fibroblast growth factor-23 (FGF23) signaling abnormalities.
  • To provide insights relevant to pediatric radiologists.

Main Methods:

  • Literature review of pediatric phosphate disorders.
  • Focus on conditions affecting FGF23 signaling.
  • Integration of findings relevant to radiological diagnosis.

Main Results:

  • Detailed discussion of various hypophosphatemic and hyperphosphatemic conditions.
  • Explanation of the role of FGF23 in these disorders.
  • Identification of key radiological features associated with phosphate imbalances.

Conclusions:

  • Understanding FGF23 signaling is vital for diagnosing and managing pediatric phosphate disorders.
  • Pediatric radiologists play a role in identifying skeletal manifestations of these conditions.
  • Accurate diagnosis and management are essential for optimal skeletal development.

Keywords:
BoneChildrenFibroblast growth factor-23Hypophosphatemic ricketsMineralizationPhosphateRadiography

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