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Updated: Sep 24, 2025
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A Machine Learning Approach to Design an Efficient Selective Screening of Mild Cognitive Impairment
Published on: January 11, 2020
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COVID-19 associated cognitive impairment: A systematic review
José W L Tavares-Júnior1, Ana C C de Souza2, José W P Borges3
1Department of Clinical Medicine, Universidade Federal do Ceará, Fortaleza, CE, Brazil.
Summary
COVID-19 infection frequently leads to cognitive impairment, affecting executive functions, attention, and memory. Further research is needed to distinguish between mild cognitive impairment and dementia post-COVID-19.
Area of Science:
- Neurology
- Infectious Diseases
- Cognitive Science
Background:
- COVID-19 presents diverse clinical symptoms, including neurological effects.
- Cognitive impairment, such as memory loss and attention deficits, is a noted manifestation.
Purpose of the Study:
- To systematically review and determine the relationship between COVID-19 and cognitive complaints.
- To investigate the occurrence of dementia, mild cognitive impairment (MCI), or subjective cognitive decline (SCD) post-infection.
Main Methods:
- Systematic review of observational studies from multiple electronic databases (MEDLINE, EMBASE, SCOPUS, LILACS).
- Inclusion criteria: confirmed COVID-19 patients with new or worsened cognitive impairment.
- Review protocol registered on PROSPERO (CRD 42021241590).
Main Results:
- Twenty-two studies involving 3,520 articles were selected.
- Commonly affected cognitive domains include executive functions, attention, and episodic memory.
- Thirteen studies indicated impairment in processing speed, attention, or executive functions.
Conclusions:
- A high frequency of cognitive impairment is observed following COVID-19 infection.
- Current data limitations prevent differentiation between mild cognitive impairment and dementia.
- Future studies should aim to clarify the specific cognitive diagnoses post-COVID-19.
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