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IL-6 blockade in cancer patients treated with immune checkpoint blockade: A win-win strategy
1Department of Dermato-Oncology, AP-HP Hopital Saint-Louis; Université Paris Cité, INSERM U976 HIPI, F-75010 Paris, France.
Abstract:
Increasing the efficacy of immune checkpoint blockade therapy while mitigating toxicity is one of the major challenges in oncology research. In this issue of Cancer Cell, Hailemichael et al. provide a strong rationale for the combination of IL-6 blockade and dual inhibition of CTLA-4 and PD-1 to overcome this issue.
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