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Related Concept Videos

Management of Insomnia01:19

Management of Insomnia

328
The sleep cycle, an integral part of human health, consists of several stages with distinct characteristics and functions. It begins with a transition from wakefulness to sleep, known as the light sleep phase, followed by the restorative deep sleep phase, essential for physical recovery and growth. The cycle concludes with the Rapid Eye Movement (REM) phase, characterized by high brain activity and vivid dreaming. Insomnia, a prevalent sleep disorder, involves difficulty falling asleep, staying...
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Sedatives and Hypnotics Drugs: Miscellaneous Agents01:17

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Sedatives and hypnotics encompass a wide range of substances, each with its unique mechanism of action, uses, and potential adverse effects.
Melatonin congeners like ramelteon (Rozerem) and tasimelteon (Hetlioz) selectively bind to melatonin receptors (MT1 and MT2) and thus mimic the actions of melatonin, a hormone that regulates sleep-wake cycles. Tasimelteon is primarily used for non-24-hour sleep-wake disorder, common in blind patients. They are also used to treat conditions like insomnia...
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CNS Depressants: Barbiturates and Benzodiazepines01:14

CNS Depressants: Barbiturates and Benzodiazepines

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CNS depressants include drugs from the category of barbiturates and benzodiazepines. They are valuable medications for managing anxiety disorders and insomnia. Barbiturates, once used to induce and maintain sleep, have been replaced mainly by benzodiazepines due to barbiturate's toxicity, tolerance, and overdose risks. They interact with GABAA receptors, leading to sedation at low doses and potentially coma and death at higher doses. Phenobarbital, a long-acting barbiturate, possesses...
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CNS Stimulants: Cocaine, Amphetamines and Cannabinoids01:24

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CNS stimulants, such as cocaine, amphetamines, and cannabinoids, have varying structures and mechanisms of action that lead to different therapeutic effects and side effects. Cocaine, with its molecular formula C17H21NO4, is a tropane alkaloid and a tertiary amino compound. It has two chemical forms: the hydrochloride salt and the "freebase." The former is in powder form, while the latter involves removing the hydrochloride salt to create a form that can be smoked. Cocaine exerts its...
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Sedatives and Hypnotics: Overview01:23

Sedatives and Hypnotics: Overview

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Sedatives are drugs that alleviate anxiety, while hypnotics induce sleep. Both classes of medication suppress neuronal activity, leading to a calming effect for sedatives and facilitating sleep for hypnotics.
Sedative-hypnotics are categorized into barbiturates, benzodiazepines (BZDs), and non-benzodiazepines or Z-drugs. These drugs work by suppressing central nervous system activity, and this suppression is dose-dependent. Older sedative medications, like barbiturates, follow a linear curve in...
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Insomnia01:27

Insomnia

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Insomnia is a prevalent sleep disorder characterized by difficulty falling asleep, frequent awakenings during the night, and waking up too early without being able to return to sleep. People with insomnia often experience these disruptions at least three nights a week for at least one month. Chronic insomnia, which lasts for at least three months, can lead to increased anxiety, which in turn can worsen sleep difficulties, creating a cycle of sleeplessness and stress.
Multiple factors contribute...
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Updated: Sep 24, 2025

Administration of &#916;9-Tetrahydrocannabinol (THC) in Adolescent and Adult Mice
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Cannabinoids, Insomnia, and Other Sleep Disorders.

Isobel Lavender1, Iain S McGregor2, Anastasia Suraev1

  • 1Centre for Sleep and Chronobiology, Woolcock Institute of Medical Research, University of Sydney, Sydney, NSW, Australia; Faculty of Science, School of Psychology, University of Sydney, Sydney, NSW, Australia; Lambert Initiative for Cannabinoid Therapeutics, University of Sydney, Sydney, NSW, Australia; Brain and Mind Centre, University of Sydney, Sydney, NSW, Australia.

Chest
|May 10, 2022
PubMed
Summary

Medicinal cannabis is explored for sleep disorders, but robust clinical evidence is limited. Further research is needed to confirm the therapeutic potential of cannabinoids for improving sleep.

Keywords:
cannabidiolcannabinolmedicinal cannabissleep disorderstetrahydrocannabinol

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Area of Science:

  • Neuroscience
  • Pharmacology
  • Sleep Medicine

Background:

  • Sleep disturbances are a primary driver for medicinal cannabis use.
  • The endocannabinoid system plays a role in regulating circadian sleep-wake cycles.
  • Clinical interest in cannabinoids for sleep disorders is growing.

Purpose of the Study:

  • To critically review current evidence on cannabinoid use for sleep disorders.
  • To overview endocannabinoid modulation of sleep-wake cycles.
  • To discuss practical clinical considerations for cannabinoid therapeutics.

Main Methods:

  • Literature review of studies on cannabinoids and sleep disorders.
  • Analysis of endocannabinoid system's role in sleep regulation.
  • Examination of plant-derived cannabinoids (THC, CBD, CBN) and their effects.

Main Results:

  • Limited high-quality studies exist, often with small sample sizes and high bias.
  • Some evidence suggests potential utility in insomnia and sleep apnea.
  • Cannabinoids like THC, CBD, and CBN have shown sleep-modulating effects.

Conclusions:

  • While interest in medicinal cannabis for sleep is high, the evidence base is not yet robust.
  • There is a strong rationale for continued research into cannabinoid therapeutics for sleep disorders.
  • Clinicians need to consider formulations, administration, side effects, and interactions.