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Gene Therapy

Gene Therapy

Gene therapy is a technique where a gene is inserted into a person’s cells to prevent or treat a serious disease. The added gene may be a healthy version of the gene that is mutated in the patient, or it could be a different gene that inactivates or compensates for the patient’s disease-causing gene. For example, in patients with severe combined immunodeficiency (SCID) due to a mutation in the gene for the enzyme adenosine deaminase, a functioning version of the gene can be...

Drug Delivery: Parenteral Route

Drug Delivery: Parenteral Route

The parenteral route is a critical method of drug administration. It delivers compounds directly into the systemic circulation and bypasses the gastrointestinal tract. This approach is particularly advantageous for drugs that exhibit poor absorption or instability when administered orally.
There are three primary parenteral routes: intravenous (IV), intramuscular (IM), and subcutaneous (SC). The IV route introduces the drug directly into the bloodstream, ensuring immediate action. The IM route...

Drug Delivery: Overview

Drug Delivery: Overview

The selection of a drug's delivery route depends upon its physicochemical properties, including lipid or water solubility and ionization, as well as the therapeutic requirement, such as immediate or sustained effect. These routes can be divided into three primary categories: enteral, parenteral, and topical.
Enteral delivery involves administering drugs directly through swallowing, sublingual placement, or buccal application. Orally administered drugs predominantly navigate the...

Microorganisms in Medicine and Therapeutics

Microorganisms in Medicine and Therapeutics

Microorganisms play a fundamental role in vaccine development, gene therapy, and therapeutic production. Their biological properties are harnessed to advance medicine and public health. Beyond immunization, microorganisms contribute to gut health, antibiotic synthesis, and genetic disease treatment.Live Attenuated and Inactivated VaccinesLive attenuated vaccines, such as the measles, mumps, and rubella (MMR) vaccine, utilize weakened forms of pathogens to closely resemble natural infections.

Drug Delivery: Miscellaneous Routes

Drug Delivery: Miscellaneous Routes

Drug delivery methods like oral inhalation, nasal sprays, transdermal patches, eye drops, intravitreal injection, and rectal administration provide localized effects with reduced toxicity.
Oral inhalation and nasal sprays swiftly transfer drugs across the respiratory epithelium's mucosal layer. Inhaled glucocorticoids and bronchodilators directly target lung conditions such as asthma, while fluticasone nasal spray mitigates allergic rhinitis.
Transdermal patches transport drugs...

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Related Experiment Video

Updated: Sep 24, 2025

Vascular Gene Transfer from Metallic Stent Surfaces Using Adenoviral Vectors Tethered through Hydrolysable Cross-linkers

Vascular Gene Transfer from Metallic Stent Surfaces Using Adenoviral Vectors Tethered through Hydrolysable Cross-linkers

Published on: August 12, 2014

Transdermal delivery for gene therapy.

Parbeen Singh¹, I'jaaz Muhammad², Nicole E Nelson²

¹Department of Mechanical Engineering, University of Connecticut, Storrs, USA.

Drug Delivery and Translational Research

|May 10, 2022

Summary

This summary is machine-generated.

Transdermal gene delivery offers a promising, low-toxicity method for genetic medicines. This review explores advanced transdermal techniques for treating skin conditions and other therapies.

Keywords:

DNA Gene therapy Microneedles Transdermal delivery mRNA miRNA siRNA

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Last Updated: Sep 24, 2025

Vascular Gene Transfer from Metallic Stent Surfaces Using Adenoviral Vectors Tethered through Hydrolysable Cross-linkers

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Published on: August 12, 2014

Development of an Economical DNA Delivery System by "Acufection" and its Application to Skin Research

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Published on: April 19, 2017

In Vivo Gene Transfer to the Rabbit Common Carotid Artery Endothelium

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Published on: May 6, 2018

Area of Science:

Biomedical Engineering
Pharmacology
Molecular Biology

Background:

Gene therapy is crucial for genetic diseases but faces delivery challenges like enzyme sensitivity, toxicity, and off-targeting.
Efficient and safe delivery of genetic materials (DNA/RNA) is vital for therapeutic advancements.

Purpose of the Study:

To systematically review and summarize innovative transdermal gene delivery methods.
To highlight the potential of transdermal delivery for enhanced efficiency and reduced toxicity in genetic medicine.

Main Methods:

Comprehensive literature search for transdermal gene delivery techniques.
Analysis of studies focusing on applications in skin cancer, vaccination, and wound healing.

Main Results:

Transdermal delivery presents an effective strategy to overcome common gene delivery obstacles.
Identified various transdermal methods showing high efficiency and low systemic toxicity for genetic medicines.

Conclusions:

Transdermal gene delivery is a viable and advantageous approach for various therapeutic applications.
Further research into transdermal methods can significantly advance genetic medicine treatments.