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Related Experiment Video

Updated: Sep 23, 2025

Three-dimensional Imaging and Analysis of Mitochondria within Human Intraepidermal Nerve Fibers
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[Metabolomics in Diabetic Neuropathy].

Qian Zhang1, Wei Song2, Xiao-Chun Liang1

  • 1Department of Traditional Chinese Medicine,PUMC Hospital,CAMS and PUMC,Beijing 100730,China.

Zhongguo Yi Xue Ke Xue Yuan Xue Bao. Acta Academiae Medicinae Sinicae
|May 11, 2022
PubMed
Summary

Metabolomics research aids understanding of diabetic neuropathy, a common complication of diabetes. Studies reveal how hyperglycemia disrupts metabolic pathways, leading to nervous system damage and potential diagnostic biomarkers.

Keywords:
diabetesdiabetic neuropathymetabolomics

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Area of Science:

  • Neuroscience
  • Metabolomics
  • Endocrinology

Background:

  • Diabetic neuropathy is a frequent complication of diabetes mellitus.
  • Persistent hyperglycemia significantly impacts nervous system function and metabolism.
  • Understanding metabolic disturbances is crucial for deciphering neuropathy pathogenesis.

Purpose of the Study:

  • To review metabolomics-based research on diabetic neuropathy over the past five years.
  • To elucidate the role of metabolic dysregulation in diabetic neuropathy.
  • To identify potential biomarkers for clinical diagnosis and treatment.

Main Methods:

  • Systematic review of metabolomics studies related to diabetic neuropathy.
  • Analysis of metabolic pathway alterations in hyperglycemia.
  • Identification of biomarkers from reviewed literature.

Main Results:

  • Hyperglycemia disrupts key metabolic pathways including the tricarboxylic acid cycle, amino acid metabolism, and lipid metabolism.
  • These metabolic alterations are linked to peripheral and central nervous system injuries.
  • Metabolomics offers insights into pathophysiological processes and potential diagnostic markers.

Conclusions:

  • Metabolomics is a valuable tool for investigating diabetic neuropathy.
  • Metabolic disturbances are central to the development of diabetic neuropathy.
  • Further research can leverage metabolomics for improved diagnosis and treatment strategies.