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Injectable Supramolecular Polymer-Nanoparticle Hydrogels for Cell and Drug Delivery Applications
Published on: February 7, 2021
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Injectable drug-loaded polysaccharide hybrid hydrogels for hemostasis
Jinying Cao1, Ling Xiao1, Xiaowen Shi1
1School of Resource and Environmental Science, Key Laboratory for Biomass Resource Chemistry and Environmental Biotechnology of Hubei Province, Wuhan University Wuhan 430079 China 2013301110176@whu.edu.cn xiaoling9119@whu.edu.cn shixwwhu@163.com.
RSC Advances
|May 11, 2022
Summary
Researchers developed an injectable hydrogel for effective hemostasis. This novel biomaterial, CMC-GEL/OSA, shows rapid gelation, strong adhesion, and significantly reduces bleeding and clotting time in wound models.
Area of Science:
- Biomaterials Science
- Polymer Chemistry
- Biomedical Engineering
Background:
- Development of advanced hemostatic agents is crucial for managing bleeding in various medical scenarios.
- Injectable hydrogels offer minimally invasive delivery and versatile application for wound management and drug delivery.
- Existing hemostatic materials often lack sufficient adhesion, biocompatibility, or cost-effectiveness.
Purpose of the Study:
- To synthesize and characterize a novel injectable adhesive hydrogel for efficient hemostasis.
- To evaluate the hemostatic, antibacterial, and drug delivery capabilities of the developed hydrogel.
- To explore the potential of Schiff-base crosslinked biopolymers for biomedical applications.
Main Methods:
- Fabrication of a hybrid hydrogel (CMC-GEL/OSA) using carboxymethyl chitosan (CMC), gelatin (GEL), and oxidized alginate (OSA) via Schiff-base linkages.
- Optimization of biopolymer concentrations to achieve desired gelation time and adhesive strength.
- In vitro assessment of antibacterial properties with levofloxacin loading and in vivo hemostatic evaluation in a rat liver injury model.
Main Results:
- The CMC-GEL/OSA hydrogel exhibited rapid gelation (30 seconds) and high adhesive strength (11 kPa).
- Freeze-dried hydrogel displayed a porous 3D structure, suitable for drug loading and tissue integration.
- Levofloxacin-loaded hydrogel demonstrated effective antibacterial activity, and in vivo tests showed an 84.2% reduction in hemostasis time and an 82.2% reduction in blood loss.
Conclusions:
- The developed injectable CMC-GEL/OSA hydrogel is a promising candidate for efficient hemostasis due to its rapid gelation, strong adhesion, and biocompatibility.
- The hydrogel's porous structure and drug-loading capacity support its potential for combined hemostatic and antimicrobial therapy.
- This Schiff-base crosslinked hydrogel presents significant potential for applications in hemostasis, drug delivery, and other regenerative medicine fields.
