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Preparation and In Vitro Characterization of Dendrimer-based Contrast Agents for Magnetic Resonance Imaging
Published on: December 4, 2016
Linear PVA-DTPA-Gd conjugate for magnetic resonance imaging
Weibing Xu1, Zhiyan Lin2, Guichen Li3
1College of Science, Gansu Agricultural University Lanzhou 730000 Gansu Province P. R. China xuwb@gsau.edu.cn +86 931 7631212.
Abstract:
In this study, we report the preparation and characterization of the PVA-DTPA-Gd conjugate as a potential MRI contrast agent (CA). The r 1 value and the r 2/r 1 ratio were about 5.6 mM-1 s-1 and 1.31, respectively. In vitro toxicity studies not only demonstrated that the polymeric system possessed good biocompatibility, but also proved that the conjugate could be an attractive candidate for CA.
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