Recent advances in the application of indoles in multicomponent reactions
Ghodsi Mohammadi Ziarani1, Razieh Moradi1, Tahereh Ahmadi1
1Department of Chemistry, Alzahra University Tehran Iran gmziarani@hotmail.com gmohammadi@alzahra.ac.ir +98 21 88041344 +98 21 88041344.
Abstract:
Indoles are some of the most versatile and common nitrogen-based heterocyclic scaffolds and are frequently used in the synthesis of various organic compounds. Indole based compounds are very important among heterocyclic structures due to their biological and pharmaceutical activities. The last decade, in particular, has witnessed considerable activity towards the synthesis of indole derivatives due to the possibilities for the design of polycyclic structures by the incorporation of multiple fused heterocyclic scaffolds in an attempt to achieve promising new heterocycles with chemical and biomedical relevance. In this study, we provide an overview on recent applications of indole in the multicomponent reactions for the synthesis of various heterocyclic compounds during the period of 2012 to 2017.
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The reaction begins with transferring a proton from the acid catalyst to one of the hydroxyl groups, producing an oxonium ion.


