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A post hoc analysis on the effects of a probiotic mixture on asthma exacerbation frequency in schoolchildren

Lorenzo Drago1, Luigi Cioffi2, Maria Giuliano2

  • 1Dept of Biomedical Sciences for Health, University of Milan, Milan, Italy.

ERJ Open Research
|May 11, 2022
PubMed

Insights

A probiotic mixture was found to significantly reduce asthma exacerbations in schoolchildren. This randomized, placebo-controlled study highlights the potential benefits of probiotics for managing childhood asthma.

Area of Science:

  • Immunology
  • Microbiology
  • Pediatrics

Background:

  • Asthma is a common chronic respiratory disease in children.
  • Asthma exacerbations significantly impact quality of life and healthcare costs.
  • Probiotics modulate the immune system and gut microbiota, potentially influencing allergic diseases.

Purpose of the Study:

  • To evaluate the efficacy of a specific probiotic mixture in reducing asthma exacerbations in schoolchildren.
  • To assess the safety and tolerability of the probiotic intervention.

Main Methods:

  • Randomised, placebo-controlled, double-blind study design.
  • Inclusion of schoolchildren diagnosed with asthma.
  • Administration of a probiotic mixture or placebo over a defined period.

Main Results:

  • Significant reduction in the number of asthma exacerbations in the probiotic group compared to placebo.
  • No significant adverse events reported in either group.
  • Potential improvements in asthma control markers observed.

Conclusions:

  • The tested probiotic mixture is effective in reducing asthma exacerbations in schoolchildren.
  • Probiotic supplementation represents a promising adjunctive therapy for pediatric asthma management.
  • Further research is warranted to elucidate the mechanisms of action and optimal use.

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