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Updated: Sep 23, 2025

Synthesis of Information-bearing Peptoids and their Sequence-directed Dynamic Covalent Self-assembly
Published on: February 6, 2020
Defined covalent assembly of protein molecules on graphene using a genetically encoded photochemical reaction handle
Athraa J Zaki1, Andrew M Hartley2, Samuel C Reddington2
1School of Physics and Astronomy, Cardiff University Cardiff CF24 3AA UK ElliottM@cardiff.ac.uk.
Abstract:
We have created modified protein variants by introducing a non-canonical amino acid p-azido-l-phenylalanine (azF) into defined positions for photochemically-induced covalent attachment to graphene. Attachment of GFP, TEM and cyt b 562 proteins was verified through a combination of atomic force and scanning tunnelling microscopy, resistance measurements, Raman data and fluorescence measurements. This method can in principle be extended to any protein which can be engineered in this way without adversely affecting its structural stability.
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