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Supramolecular hydrogels encapsulating bioengineered mesenchymal stem cells for ischemic therapy
Byung Woo Hwang1, Young-Eun Kim2, Mungu Kim3
1Department of Materials Science and Engineering, Pohang University of Science and Technology (POSTECH) 77 Cheongam-ro Pohang 37673 Korea.
RSC Advances
|May 11, 2022
Abstract:
We developed supramolecular hyaluronate (HA) hydrogels to encapsulate genetically engineered mesenchymal stem cells (MSCs) for the treatment of limb ischemia. In vivo angiogenic factors could be produced stably by the bioengineered MSCs (BMSCs) within the supramolecular hydrogels showing effective vascular repair and enhanced blood perfusion.
