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Schweinfurthins A-Q: isolation, synthesis, and biochemical properties
Dipesh S Harmalkar1, Jyotirling R Mali1, Aneesh Sivaraman1
1College of Pharmacy, Dongguk University-Seoul Goyang 10326 Republic of Korea kaylee@dongguk.edu.
RSC Advances
|May 11, 2022
Summary
Schweinfurthins, natural stilbene compounds from Macaranga plants, show potent anticancer activity. This review details their isolation, synthesis, and biochemical properties, highlighting their potential as selective cell growth inhibitors.
Area of Science:
- Natural Product Chemistry
- Medicinal Chemistry
- Organic Synthesis
Background:
- Stilbene analogues exhibit diverse structures and significant interest in synthetic and medicinal chemistry.
- Schweinfurthins are prenylated/geranylated/farnesylated stilbenes isolated from the African plant Macaranga species.
- These compounds have demonstrated activity against central nervous system, renal, and breast cancer cell lines.
Purpose of the Study:
- To review the isolation and synthesis of schweinfurthins.
- To discuss the biochemical properties of schweinfurthins.
- To highlight the anticancer potential of schweinfurthins.
Main Methods:
- Isolation of natural products from Macaranga species.
- Chemical synthesis of schweinfurthins.
- Biochemical assays to determine inhibitory effects on cell growth.
Main Results:
- Schweinfurthins were isolated from Macaranga species.
- Synthetic routes for schweinfurthins were established.
- Schweinfurthins were identified as potent and selective inhibitors of cell growth in the NCI-60 cell line screen.
Conclusions:
- Schweinfurthins represent a promising class of natural products with significant anticancer potential.
- Further research into schweinfurthins could lead to novel therapeutic agents.
- The synthetic accessibility and potent biological activity of schweinfurthins warrant continued investigation.
