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Pancreatic duct obliteration: clinical application, morphological and functional effects
The Netherlands Journal of Surgery
|February 1, 1987
Summary
Pancreatic duct obliteration safely stops exocrine function but may severely impair endocrine function. Further research is needed to determine if this procedure is suitable for pancreas transplantation in humans.
Area of Science:
- Gastroenterology
- Surgical Procedures
- Endocrinology
Background:
- Pancreatic duct obliteration is used to prevent complications after pancreatic surgery.
- It is applied after partial pancreatic resections and pancreas transplantation.
- While safe, its impact on endocrine function is not fully understood in humans.
Purpose of the Study:
- To investigate the effects of pancreatic duct obliteration on endocrine function.
- To determine if the procedure is suitable for pancreas transplantation.
Main Methods:
- The study reviews existing literature and experimental data on pancreatic duct obliteration.
- Experimental data from canine studies are considered.
Main Results:
- Pancreatic duct obliteration leads to exocrine atrophy.
- Canine studies show a significant reduction (approx. 70%) in insulin secretion capacity.
- The impact on human endocrine function remains unknown.
Conclusions:
- Pancreatic duct obliteration causes significant exocrine atrophy.
- The procedure may severely damage endocrine architecture and insulin secretion.
- Its suitability for pancreas transplantation in type-I diabetes mellitus patients requires further investigation.