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Updated: Sep 23, 2025

Evidence-based Knowledge Synthesis and Hypothesis Validation: Navigating Biomedical Knowledge Bases via Explainable AI and Agentic Systems
Published on: June 13, 2025
Putting explainable AI in context: institutional explanations for medical AI
Mark Theunissen1, Jacob Browning2
1Department of Values, Technology and Innovation, School of Technology, Policy and Management, Delft University of Technology, Delft, The Netherlands.
Machine learning in medicine requires institutional explanations, not just individual decision explanations. This approach addresses medical professionals' trust and ensures reliable use of AI tools.
Area of Science:
- Medical Informatics
- Artificial Intelligence
- Philosophy of Science
Background:
- The explainability of machine learning (ML) systems in medicine is debated.
- Arguments exist for post hoc explanations versus relying solely on system accuracy.
- Current approaches may not fully address medical professionals' epistemic concerns.
Purpose of the Study:
- To evaluate the necessity and nature of explainability for medical ML systems.
- To propose an alternative framework for justifying the use of these systems.
- To enhance the epistemic justification for medical professionals using ML tools.
Main Methods:
- Conceptual analysis of explainability in ML for healthcare.
- Examination of limitations in post hoc explanations and accuracy-based justifications.
- Development of the concept of 'institutional explanation' for ML systems.
Main Results:
- Both post hoc explanations and high accuracy have limitations in addressing user trust.
- Individual decision explanations do not fully resolve epistemic worries of medical professionals.
- An institutional explanation framework is proposed to build trust and ensure reliable use.
Conclusions:
- Medical ML systems require institutional explanations focusing on practical reliance.
- Transparency in system design, evaluation metrics, and bias auditing is crucial.
- Institutional explanations make accuracy and post hoc explanations more meaningful for end-users.
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