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Updated: Sep 23, 2025

A Large Animal Model for Pulmonary Hypertension and Right Ventricular Failure: Left Pulmonary Artery Ligation and Progressive Main Pulmonary Artery Banding in Sheep
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PARP1-PKM2 Axis Mediates Right Ventricular Failure Associated With Pulmonary Arterial Hypertension

Tsukasa Shimauchi1, Olivier Boucherat1,2, Tetsuro Yokokawa1

  • 1Pulmonary Hypertension Research Group, Centre de Recherche de l'Institut Universitaire de Cardiologie et de Pneumologie de Québec, Québec, Québec, Canada.

JACC. Basic to Translational Science
|May 11, 2022
PubMed

Keywords:
CM, cardiomyocyteCO, cardiac outputET, endothelinNF-κB, nuclear factor κBPAB, pulmonary artery bandingPAH, pulmonary arterial hypertensionPARP1PARP1, poly(adenosine diphosphate–ribose) polymerase 1PKM2PKM2, pyruvate kinase muscle isozyme 2RV, right ventricularSTAT3, signal transducer activator of transcription 3WT, wild-typecKO, conditional knockoutpulmonary hypertensionright ventricle

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