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Panax notoginseng saponins radiosensitize colorectal cancer cells by regulating the SNHG6/miR-137 axis

Caihui Xu1, Teng Liu2, Haiyan Liu1

  • 1Department of Oncology, Shangqiu First People's Hospital No. 292, South Kaixuan Road, Suiyang District Shangqiu 476100 Henan China guoym18917@163.com +86-0370-3255630.

RSC Advances
|May 11, 2022
PubMed

Insights

Panax notoginseng saponins (PNS) enhance colorectal cancer (CRC) cell radiosensitivity. PNS promotes radiosensitivity by upregulating SNHG6, which targets miR-137, offering a new therapeutic strategy for CRC.

Area of Science:

  • Oncology
  • Molecular Biology
  • Pharmacology

Background:

  • Colorectal cancer (CRC) remains a significant global health challenge.
  • Panax notoginseng saponins (PNS) show potential anti-cancer properties.
  • The role of PNS in CRC radiosensitivity requires further elucidation.

Purpose of the Study:

  • To investigate the functional role of PNS in colorectal cancer radiosensitivity.
  • To explore the underlying molecular mechanisms of PNS action in CRC.
  • To determine the involvement of the SNHG6/miR-137 axis in PNS-mediated radiosensitization.

Main Methods:

  • Cell viability assays (Cell Counting kit-8).
  • Colony formation and flow cytometry for cell survival and apoptosis.
  • Quantitative real-time PCR for SNHG6 and miR-137 expression.
  • Dual-luciferase reporter and RNA immunoprecipitation assays for target validation.

Main Results:

  • PNS significantly reduced colorectal cancer cell viability.
  • PNS treatment enhanced the radiosensitivity of CRC cells.
  • PNS upregulated SNHG6 expression, which directly targeted and inhibited miR-137.
  • PNS promoted CRC cell radiosensitivity via the SNHG6/miR-137 pathway.

Conclusions:

  • PNS exhibits radiosensitizing effects in colorectal cancer.
  • The SNHG6/miR-137 axis is a key mediator of PNS's radiosensitizing activity in CRC.
  • PNS represents a potential therapeutic agent for enhancing CRC radiosensitivity.

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