Cu-catalyzed mild and efficient oxidation of THβCs using air: application in practical total syntheses of perlolyrine
Bo Zheng1, Tien Ha Trieu1, Tian-Zhuo Meng1
1Shanghai Key Laboratory of Chemical Biology, School of Pharmacy, East China University of Science and Technology 130 Mei-Long Road Shanghai 200237 P. R. China xxshi@ecust.edu.cn.
Abstract:
A mild, efficient and environmentally benign method for synthesis of aromatic β-carbolines via Cu(ii)-catalyzed oxidation of 1,2,3,4-tetrahydro-β-carbolines (THβCs) was developed, in which air (O2) was used as the clean oxidant. This method has advantages such as environmentally friendliness, mildness, very good tolerance of functional groups, high yielding and easy experiment operation. In addition, this new methodology was successfully applied in the efficient and practical total syntheses of β-carboline alkaloids perlolyrine and flazin.
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