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Massive periorbital edema following hematopoietic stem cell transplantation
Jeannette Y Stallworth1, Jonathan C Horton1
1University of California San Francisco, Department of Ophthalmology, San Francisco, CA, 94158 USA.
Purpose:
To describe a case of severe, bilateral periorbital edema after hematopoietic stem cell transplantation.
Observations:
A three-year old girl with metastatic neuroblastoma underwent the second of two tandem autologous peripheral blood stem cell transplants, complicated by engraftment syndrome. On post-engraftment day 11, she developed acute onset of severe periorbital edema. She was soon thereafter diagnosed with transplant-associated thrombotic microangiopathy with significant volume overload requiring treatment with eculizumab and etanercept. Periorbital edema resolved after four days with concurrent treatment of her underlying condition.
Conclusions And Importance:
We report an ocular manifestation related to complications of hematopoietic stem cell transplantation. This highlights a non-infectious etiology of eyelid swelling in the post-transplant, immunocompromised population.
