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No child should suffer from vitamin K deficiency-induced bleeding disorders

Masazumi Miyahara1, Kyoko Osaki1

  • 1Department of Pediatrics Okanami General Hospital Iga Japan.

Clinical Case Reports
|May 11, 2022
PubMed

Insights

A neonate developed intracranial hemorrhage from vitamin K deficiency despite oral prophylaxis. Current vitamin K deficiency-bleeding prevention programs may be insufficient, necessitating improved strategies.

Area of Science:

  • Neonatal Medicine
  • Hematology
  • Pharmacology

Background:

  • Vitamin K deficiency-bleeding (VKDB) is a preventable condition in newborns.
  • Japanese guidelines recommend oral vitamin K2 (menaquinone-4) prophylaxis for VKDB prevention.
  • Despite prophylaxis, breakthrough bleeding events can occur.

Observation:

  • An 11-day-old male neonate presented with intracranial hemorrhage.
  • The neonate had received oral vitamin K2 (menaquinone-4) prophylaxis as per Japanese guidelines.
  • This indicates a potential failure of the current prophylactic regimen.

Findings:

  • The case highlights that oral vitamin K2 prophylaxis alone may not fully prevent VKDB.
  • Intracranial hemorrhage occurred despite adherence to established prophylactic protocols.
  • This suggests limitations in the current standard of care for VKDB prevention.

Implications:

  • Current VKDB prophylaxis programs may require revision to enhance efficacy.
  • Combined intramuscular and oral vitamin K administration should be explored for improved protection.
  • Further research is needed to optimize VKDB prevention strategies for neonates.

Keywords:
intracranial hemorrhageprophylaxisvitamin K deficiency bleeding

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