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Related Experiment Videos

Acanthosis nigricans.

H O Sedano, R J Gorlin

    Oral Surgery, Oral Medicine, and Oral Pathology
    |April 1, 1987
    PubMed
    Summary

    Acanthosis nigricans (AN) presents as velvety skin lesions, often affecting the neck and mouth. This review highlights oral AN manifestations and their links to insulin resistance and stomach cancer.

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    Area of Science:

    • Dermatology
    • Oncology
    • Endocrinology

    Background:

    • Acanthosis nigricans (AN) is a skin condition with velvety, hyperkeratotic macules and papillomatous growths.
    • AN commonly affects skin folds like the axilla and neck, but also the oral cavity.
    • AN is associated with internal malignancies, particularly gastric adenocarcinoma, and insulin resistance.

    Purpose of the Study:

    • To review the oral manifestations of Acanthosis nigricans.
    • To emphasize the diagnostic importance of oral AN findings.
    • To discuss the association of oral AN with underlying systemic conditions.

    Main Methods:

    • Literature review of studies on Acanthosis nigricans.
    • Analysis of clinical presentations of oral AN.
    • Correlation of oral AN with associated pathologies.

    Main Results:

    • Oral AN presents with characteristic pigmentation, papillomatosis, and velvety texture within the oral cavity.
    • Oral manifestations of AN can be an early indicator of underlying disease.
    • Significant associations found between AN and insulin resistance (diabetes) and gastric adenocarcinoma.

    Conclusions:

    • Oral Acanthosis nigricans is a significant clinical sign requiring thorough investigation.
    • Recognition of oral AN is crucial for early diagnosis of associated systemic diseases.
    • Further research into the pathogenesis and management of oral AN is warranted.

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