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Updated: Sep 23, 2025

A Pipette-Tip Based Method for Seeding Cells to Droplet Microfluidic Platforms

A Pipette-Tip Based Method for Seeding Cells to Droplet Microfluidic Platforms

Published on: February 11, 2019

An open-source programmable smart pipette for portable cell separation and counting.

Eunjung Lee¹, Byeongyeon Kim², Sungyoung Choi²

¹Department of Biomedical Engineering, Kyung Hee University Yongin-si Gyeonggi-do 17104 Republic of Korea.

|May 11, 2022

Summary

This summary is machine-generated.

We developed an open-source, programmable smart pipette to simplify microfluidic applications. This handheld pump offers precise, programmable flow control for cell separation and counting, enhancing accessibility for researchers.

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Area of Science:

Biomedical Engineering
Microfluidics
Open-Source Technology

Background:

Microfluidics holds significant promise for biomedical applications.
Widespread adoption is hindered by complex, inconvenient, and inaccessible pumping equipment.

Purpose of the Study:

To introduce an open-source, programmable smart (OS) pipette.
To overcome limitations of existing microfluidic pumps with an easy-to-use, handheld device.

Main Methods:

The OS pipette utilizes a stepper motor to precisely control a positive-displacement micropipette plunger.
An open-source microcontroller board enables programmable flow rate generation (constant, variable, pulsed).

Main Results:

Demonstrated simple fabrication and straightforward operation of the OS pipette.
Achieved precise, predictable, and programmable flow rates.
Validated the OS pipette for portable microfluidic cell separation and counting.

Conclusions:

The OS pipette is a versatile, open-source tool for microfluidics.
It offers unrestricted use, modification, and broad applicability, even for non-experts.
This technology has the potential to transform microfluidic device accessibility and application.