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Association between metabolic profile and microbiomic changes in rats with functional dyspepsia.

Liang Luo¹, Minghua Hu², Yuan Li¹

¹School of Pharmaceutical Sciences, Guangzhou University of Chinese Medicine Guangzhou 510006 China liaoqf2075@yahoo.com +86 20 3958081 +86 20 3958081.

|May 11, 2022

Summary

Functional dyspepsia (FD) is linked to gut microbiota and host metabolism changes. This study reveals specific microbial shifts and metabolic alterations, suggesting FD arises from gut dysbiosis and metabolic dysfunction.

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Area of Science:

Gastroenterology and Metabolism
Microbiome Research

Background:

Functional dyspepsia (FD) is a common functional gastrointestinal disorder (FGID).
The link between FD, gut microbiota, and host metabolic changes remains unclear.

Purpose of the Study:

To investigate the relationship between FD, gut microbiota, and host metabolism.
To clarify host-microbiota co-metabolism disorders in FD.

Main Methods:

Integrated approach using 1H NMR-based metabolomics, PCR-DGGE, and 16S rRNA gene sequencing.
Analysis of urinary and fecal metabolites and gut microbial composition in FD models.

Main Results:

Identified 34 differential urinary and 19 fecal metabolites associated with FD, impacting energy, amino acid, nucleotide, and short-chain fatty acid (SCFA) metabolism.
Screened 10 diagnostic biomarkers for FD using ROC analysis.
Observed significant alterations in specific gut bacteria (e.g., increased Flintibacter, decreased Eisenbergiella) correlated with metabolic changes.

Conclusions:

FD is associated with significant gut microbiota dysbiosis and host metabolic disturbances, particularly in energy metabolism.
Gut microbiota and metabolism disorders are potential contributors to the pathogenesis of FD.
Findings offer insights into FD pathogenesis and potential therapeutic targets.