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Updated: Sep 23, 2025

Facile Preparation of 2Z,4E-Dienamides by the Olefination of Electron-deficient Alkenes with Allyl Acetate
Published on: June 21, 2017
Copper-catalyzed aerobic decarboxylative coupling between cyclic α-amino acids and diverse C-H nucleophiles with low
Jing Guo1, Ying Xie1, Qiao-Lei Wu1
1Institute of Medicinal Chemistry, School of Pharmaceutical Sciences, Sun Yat-sen University Guangzhou 510006 China lugui@mail.sysu.edu.cn wengj2@mail.sysu.edu.cn +86-20-3994-3048.
Abstract:
An aerobic decarboxylative cross-coupling of α-amino acids with diverse C-H nucleophiles has been realized using Cu2(OH)2CO3 (1 mol%) as the catalyst under air. This protocol enables highly efficient formation of various C(sp3)-C(sp3), C(sp3)-C(sp2) and C(sp3)-C(sp) bonds under simple conditions without the use of any ligand or extra oxidant, providing a practical approach to numerous nitrogen-containing compounds in good to excellent yields. The efficiency and practicability were also demonstrated by the gram-scale experiment and three-step synthesis of a Rad51 inhibitor.
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