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Updated: Sep 23, 2025

Biological Compatibility Profile on Biomaterials for Bone Regeneration
Published on: November 16, 2018
Biological properties of calcium phosphate biomaterials for bone repair: a review
Jingyi Lu1,2,3, Huijun Yu1,2,3, Chuanzhong Chen1,4
1Shenzhen Research Institute of Shandong University Shenzhen 518057 Guangdong P. R. China yhj2001@sdu.edu.cn czchen@sdu.edu.cn +86 531 88395991 +86 531 88395991.
Abstract:
Bone defects are a common disease threatening the health of many people. Calcium phosphate (CaP) is an ideal bone substitutive material that is widely used for bone repair due to its excellent biological properties including osteoinductivity, osteoconductivity and biodegradability. For this reason, investigation of these properties and the effects of various influencing factors is vital for modulating calcium phosphate during the design process to maximally satisfy clinical requirements. In this study, the latest studies on the biological properties of CaP biomaterials, including hydroxyapatite (HA), tricalcium phosphate (TCP), and biphasic calcium phosphate (BCP), have been summarized. Moreover, recent advances on how these properties are altered by different factors are reviewed. Considering the limited mechanical strength of CaP materials, this study also reviews CaP composites with different materials as improvement measures. Finally, perspectives regarding future developments of CaP materials are also provided.
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