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Updated: Sep 23, 2025

Protocols for Testing the Toxicity of Novel Insecticidal Chemistries to Mosquitoes
Published on: February 13, 2019
Synthesis and insecticidal activities of 5-deoxyavermectin B2a oxime ester derivatives
Guoshao Sun1, Jingjing Zhang1, Shuhui Jin1
1Department of Applied Chemistry, College of Science, China Agricultural University Beijing 100193 P. R. China zhangjianjun@cau.edu.cn.
Abstract:
Three series of avermectin B2a oxime ester derivatives were synthesized using avermectin B2a as starting material. All of the compounds were characterized by 1H NMR, 13C NMR, and HRMS. Bioassay results indicated that some of the derivatives (8b, 8c, 8d, 8f, 11k, 11l, 14c, 14j) showed potent insecticidal activities against Myzus persicae, Caenorhabditis elegans, or Tetranychus cinnabarinus. As shown by initial insecticidal activity data, compound 8d showed excellent activities (>90%) against M. persicae and C. elegans, which were more potent than that of avermectin B2a. Compound 8d might be a lead compound for designing new avermectin B2a derivatives.
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