Left Atrial Appendage Closure with the LAmbre Device - Initial Multicentre Experience in Brazil

Area of Science:

• Cardiology
• Medical Devices
• Interventional Procedures

Background:

• Left atrial appendage (LAA) closure offers an alternative to oral anticoagulation (OAC) for stroke prevention in patients with non-valvular atrial fibrillation (NVAF).
• This study focuses on LAA closure as a therapeutic option for NVAF patients who cannot tolerate long-term OAC.

Purpose of the Study:

• To report the initial multicenter experience in Brazil with LAA closure using the LAmbre device.
• To evaluate the feasibility, safety, and efficacy of the LAmbre device for LAA occlusion in NVAF patients.

Main Methods:

• A total of 51 consecutive NVAF patients underwent LAA closure with the LAmbre device across 18 centers in Brazil.
• Patients had restrictions for long-term OAC due to bleeding, stroke, or other contraindications.
• Procedural and follow-up data were collected, including device success and complication rates.

Main Results:

• The study included 51 patients (49% male, 51% female) with a mean age of 76 years and high CHA2DS2-VASc and HAS-BLED scores.
• Procedural success rate was 100%, with minor immediate complications in 3 patients (pericardial effusion, device embolization).
• After a mean follow-up of 18 months, no deaths or strokes were reported, with small residual shunts in 4 patients.

Conclusions:

• LAA occlusion with the LAmbre device demonstrated safety and effectiveness in this initial series of NVAF patients.
• The findings suggest LAmbre is a viable option for stroke prevention in patients unsuitable for OAC.
• Further research with larger cohorts and longer follow-up is recommended to confirm these encouraging results.