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COVID-19 and retinal degenerative diseases: Promising link "Kaempferol"
1Apoptosis and Cell Survival Research Laboratory, 412G Pearl Research Park, School of Biosciences and Technology, Vellore Institute of Technology, Vellore, 632014, Tamil Nadu, India.
Insights
Natural flavonoids like Kaempferol show promise for managing COVID-19 complications, including vision loss and macular degeneration. This review explores Kaempferol
Area of Science:
- Nutritional science
- Immunology
- Ophthalmology
Background:
- The COVID-19 pandemic has caused widespread health issues, particularly in the elderly, with emerging complications like macular degeneration and vision loss.
- Natural compounds, specifically flavonoids, have a history in traditional medicine and are being investigated for their therapeutic potential against viral infections and associated conditions.
- Kaempferol, a key flavonoid, modulates critical cellular pathways including apoptosis, angiogenesis, inflammation, and autophagy, suggesting a role in disease management.
Purpose of the Study:
- To review the potential regulatory effects of Kaempferol on the pathological hallmarks of COVID-19.
- To explore the therapeutic implications of Kaempferol in mitigating macular degeneration and vision loss associated with post-COVID syndrome.
Main Methods:
- Literature review of existing studies on Kaempferol, COVID-19, and macular degeneration.
- Analysis of Kaempferol's known effects on cellular signaling pathways relevant to disease pathogenesis.
Main Results:
- Kaempferol influences key cellular processes implicated in both COVID-19 and macular degeneration.
- Evidence suggests Kaempferol's potential to counteract inflammatory and apoptotic pathways relevant to these conditions.
Conclusions:
- Kaempferol presents a promising natural therapeutic agent for addressing post-COVID complications, including ocular conditions like macular degeneration.
- Further research into Kaempferol's efficacy and mechanisms is warranted for clinical application in managing COVID-19 sequelae and vision impairment.
Abstract:
Coronavirus disease (COVID-19) outbreak has caused unprecedented global disruption since 2020. Approximately 238 million people are affected worldwide where the elderly succumb to mortality. Post-COVID syndrome and its side effects have popped up with several health hazards, such as macular degeneration and vision loss. It thus necessitates better medical care and management of our dietary practices. Natural flavonoids have been included in traditional medicine and have also been used safely against COVID-19 and several other diseases. Kaempferol is an essential flavonoid that has been demonstrated to influence several vital cellular signaling pathways involved in apoptosis, angiogenesis, inflammation, and autophagy. In this review, we emphasize the plausible regulatory effects of Kaempferol on hallmarks of COVID-19 and macular degeneration.
