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Updated: Sep 23, 2025

Cefoperazone-treated Mouse Model of Clinically-relevant Clostridium difficile Strain R20291
Published on: December 10, 2016
The role of short-chain fatty acids in Clostridioides difficile infection: A review
Zi-Rou Ouyang1, Xiao-Ran Niu1, Wei-Gang Wang1
1Second Hospital of Hebei Medical University, 215 Hepingxi Road, Shijiazhuang City, Hebei Province, 050000, China; Hebei Provincial Center for Clinical Laboratories, 215 Hepingxi Road, Shijiazhuang City, Hebei Province, 050000, China.
Abstract:
Clostridioides difficile is a Gram-positive, obligate anaerobic, spore-producing intestinal opportunistic pathogen. CDI outbreaks in Europe and the Americas in recent years are a major health concern. Intestinal short-chain fatty acids (SCFAs) are an important energy source for colonic epithelial cells, and the roles of SCFAs in reducing intestinal inflammation, inhibiting intestinal tumors, and regulating gut microbial homeostasis are being actively researched. Furthermore, SCFAs attenuate CDI or directly inhibit C. difficile growth through different pathways in vivo and in vitro. This review assesses the role of SCFAs in CDI and discusses the potential use of these molecules as therapeutic targets for CDI.
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