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International Expert Consensus and Recommendations for Neonatal Pneumothorax Ultrasound Diagnosis and Ultrasound-guided Thoracentesis Procedure
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Published on: March 12, 2020

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Severe bronchopulmonary dysplasia in extremely premature infants: a scoping review protocol for identifying risk

Shin Kato1, Masato Ito2, Makoto Saito3

  • 1Department of Pediatrics and Neonatology, Nagoya City University Graduate School of Medical Sciences, Nagoya, Aichi, Japan shink@med.nagoya-cu.ac.jp.

BMJ Open
|May 11, 2022
PubMed

Insights

This scoping review identifies perinatal risk factors for severe bronchopulmonary dysplasia (BPD) in extremely premature infants. Findings aim to improve early detection and inform new classification systems for better long-term infant prognoses.

Area of Science:

  • Neonatal Medicine
  • Pediatric Pulmonology
  • Public Health

Background:

  • Improved survival rates for extremely premature infants have increased bronchopulmonary dysplasia (BPD) incidence.
  • BPD significantly impacts infant pulmonary function and long-term developmental outcomes, creating a substantial health burden.
  • Identifying early risk factors and developing better preventative and treatment strategies for BPD are crucial.

Purpose of the Study:

  • To conduct a scoping review of existing evidence on perinatal risk factors for BPD.
  • To identify key factors contributing to the development and severity of BPD.
  • To propose a novel disease classification system for predicting long-term BPD prognosis.

Main Methods:

  • Systematic screening of articles published between 2002-2021 from developed countries.
  • Inclusion of randomized controlled trials, cohort studies, and case-control studies focusing on infants born before 28 weeks gestational age.
  • Data extraction and analysis using the population-concept-context framework to identify perinatal risk factors and associated statistical measures (RR/OR, 95% CI, p-values).

Main Results:

  • The review will compile and present identified perinatal risk factors for severe BPD.
  • Quantitative data (risk ratios or odds ratios, confidence intervals, p-values) will be provided for significant risk factors.
  • A comprehensive overview of current evidence on BPD risk factors will be established.

Conclusions:

  • This review will elucidate critical perinatal risk factors associated with severe BPD.
  • The findings will support the development of a new classification system to predict long-term infant prognosis.
  • Evidence-based insights will guide improved prophylactic and therapeutic strategies for BPD.
Abstract

Keywords:
NEONATOLOGYPERINATOLOGYPaediatric thoracic medicine

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